Increased enhancement of tumour response to X-rays and high-LET neon ions by desmethylmisonidazole relative to misonidazole.
Increased enhancement of tumour response to X-rays and high-LET neon ions by desmethylmisonidazole relative to misonidazole.
复制标题
相对于米索硝唑，去甲基米索硝唑增强了肿瘤对 X 射线和高 LET 氖离子的反应。
DOI：
10.1080/09553008214550771
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Lyman,JT
中科院分区：
文献类型：
--
作者：
Tenforde,TS;Curtis,SB;Parr,SS;Afzal,SM;Howard,J;Lyman,JT
2. 2.1材料和方法横纹肌肉瘤肿瘤和体积反应测量用皮下移植到同系WAG/Rij大鼠胸部的横纹肌肉瘤R-1肿瘤测量辐射诱导的生长延迟（Barendsen和Broerse 1969，1970）。在这些实验中使用的肿瘤亚系，命名为R1/LBL，先前用于测量用氦、碳、氖和氩离子的加速束照射后的生长延迟（Curtis等人，1978年; Tenforde等人，1981年B），并与碳和氖离子与米索硝唑联合给药（Tenforde等，1981 a）。使用先前描述的方法（Curtis等，1978），通过卡尺测量肿瘤体积，监测辐射后R1/LBL肿瘤的消退和再生长。辐射诱导的生长延迟计算从照射和未照射的肿瘤生长到照射当天测量的体积的两倍的时间差。在这些实验中使用的肿瘤的平均初始体积为0。53±0.03（SE）cm 3，该尺寸的未照射肿瘤的体积倍增时间为4。5天
2. Materials and methods 2.1. Rhabdomyosarcoma tumours and volume response measurements Measurements of radiation-induced growth delay were made with rhabdomyosarcoma R-1 tumours transplanted subcutaneously in the thoracic region of syngeneic WAG/Rij rats (Barendsen and Broerse 1969, 1970). The tumour subline used in these experiments, designated R1/LBL, was previously used for measurements of growth delay following irradiation with accelerated beams of helium, carbon, neon and argon ions (Curtis et al. 1978, Tenforde et al. 1981 b), and with carbon and neon ions administered in combination with misonidazole (Tenforde et al. 1981 a).The regression and regrowth of R1/LBL tumours following irradiation were monitored by caliper measurements of tumour volume using methods described previously (Curtis et al. 1978). Radiation-induced growth delay was calculated from the difference in time for irradiated and nonirradiated tumours to grow to twice their volumes measured on the day of irradiation. The average initial volume of the tumours used in these experiments was 0. 53±0.03 (SE) cm3, and the volume doubling time for nonirradiated tumours of this size was 4. 5 days.