QUANTIFICATION OF CYTOCHROME-P450 REDUCTASE GENE-EXPRESSION IN HUMAN TISSUES
QUANTIFICATION OF CYTOCHROME-P450 REDUCTASE GENE-EXPRESSION IN HUMAN TISSUES
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DOI：
10.1016/0003-9861(92)90152-m
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发表时间：
1992-04-01
影响因子：
3.9
通讯作者：
PHILLIPS, IR
中科院分区：
文献类型：
--
作者：
SHEPHARD, EA;PALMER, CNA;PHILLIPS, IR
我们已经分离并测序了编码人细胞色素P450还原酶变体的cDNA克隆。RNA酶保护试验用于定量成人和胎儿组织中相应的mRNA。结果表明，在所分析的样品中，细胞色素P450还原酶基因在成人肝脏中的表达显示出很小的个体间差异，并且很少受到发育或组织特异性调节。
We have isolated and sequenced cDNA clones that code for a variant of human cytochrome P450 reductase. An RNase protection assay was used to quantify the corresponding mRNA in adult and fetal tissues. The results demonstrate that, in the samples analyzed, the cytochrome P450 reductase gene displays very little interindividual variation in its expression in adult liver and is subject to little developmental or tissue-specific regulation.