Medium-dose UVA1 phototherapy in localized scleroderma and its effect in CD34-positive dendritic cells
Medium-dose UVA1 phototherapy in localized scleroderma and its effect in CD34-positive dendritic cells
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DOI：
10.1067/mjd.2001.117735
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发表时间：
2001-11-01
影响因子：
13.8
通讯作者：
Sánchez, JL
中科院分区：
文献类型：
--
作者：
Camacho, NR;Sánchez, JE;Sánchez, JL
背景。 UVA1 辐射似乎对硬斑病有效。硬斑病患者皮损皮肤中CD34(+)树突状细胞明显减少。目的：评价中近距离UVA1光疗对局限性硬皮病的治疗效果及其对患者皮肤活检标本中真皮CD34(+)树突状细胞数量的影响。方法：对患者进行UVA1(30 J/cm(2))照射30次。治疗前后对真皮CD34(+)树突状细胞进行计数。结果：UVA1照射后临床有所改善。 UVA1照射后真皮CD34(+)树突状细胞明显增多。结论：中近距离UVA1治疗对治疗局限性硬斑病有效，疗效与真皮中CD34(+)树突状细胞数量增加有关。
Background. UVA1 radiation seems to be effective in morphea. CD34(+) dendritic cells are significantly decreased in lesional skin of morphea patients.Objective: We evaluated the therapeutic effectiveness of medium-close UVA1 phototherapy, in localized scleroderma and its effect in the number of dermal CD34(+) dendritic cells in skin biopsy specimens of these patients.Method: Patients were irradiated with UVA1 (30 J/cm(2)) 30 times. Dermal CD34(+) dendritic cells were counted before and after therapy.Results: There was clinical improvement after UVA1 irradiation. Dermal CD34(+) dendritic cells significantly increased after UVA1 irradiation.Conclusion: Medium-close UVA1 therapy is effective in the treatment of localized morphea, Effectiveness is associated with an increase in the number of CD34(+) dendritic cells in the dermis.