Social network and development of prediabetes and type 2 diabetes in middle-aged Swedish women and men
Social network and development of prediabetes and type 2 diabetes in middle-aged Swedish women and men
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DOI：
10.1016/j.diabres.2014.09.057
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发表时间：
2015-01-01
影响因子：
5.1
通讯作者：
Ostenson, Claes-Goran
中科院分区：
文献类型：
--
作者：
Hilding, Agneta;Shen, Chong;Ostenson, Claes-Goran
目的：探讨社会网络是否影响糖尿病前期和2型糖尿病的发展。方法：在基线时葡萄糖耐量正常的个体，2924名女性和2039名男性，年龄35-56岁，随访8-10年后进行口服葡萄糖耐量试验。女性分别有168名和50名，男性分别有236名和93名患前驱糖尿病和2型糖尿病。基线时通过问卷记录的社会网络（avsi -指数（社会整合可用性）、公民身份和社会活动参与）测量，通过逻辑回归进行评估。结果：AVSI评分在最高分值与女性患2型糖尿病的风险降低相关（年龄校正优势比为0.41 [95% CI: 0.19-0.88]），完全校正后的优势比为0.50[0.22-1.16])。相反，在完全调整后，男性AVSI与2型糖尿病发生风险增加相关（1.93[1.03-3.60]）。参加社交活动降低了女性患前驱糖尿病和2型糖尿病的风险（年龄调整后分别为0.65[0.46-0.91]和0.43[0.24-0.77]），经混杂因素调整后的显著性较低（0.78[0.54-1.12]和0.59[0.31-1.13]）。在男性中，观察到前驱糖尿病的风险降低（0.59[0.43-0.82]）。只有男性结婚或与伴侣同居降低了2型糖尿病的风险（年龄和多因素调整模型分别为0.57[0.33-0.97]和0.61[0.34-1.08]）。结论：拥有社交网络的个体似乎不太可能出现异常的血糖调节。与拥有社交网络的整体保护模式相反，男性高avsi指数增加了患2型糖尿病的风险。2014爱思唯尔爱尔兰有限公司版权所有。
Aim: Explore if social network affects development of prediabetes and type 2 diabetes.Methods: Individuals with normal glucose tolerance at baseline, 2924 women and 2039 men, aged 35-56 years, were followed-up 8-10 years later by an oral glucose tolerance test. Prediabetes and type 2 diabetes was then evident in 168 and 50 women and in 236 and 93 men, respectively. Measures of social network (AVSI-index (availability of social integration), civil status and participation in social activities), recorded by questionnaire at baseline, were evaluated by logistic regression.Results: Having AVSI scores in the highest tertile was associated with a decreased risk to develop type 2 diabetes in women (age-adjusted odds ratio 0.41 [95% CI: 0.19-0.88]) less significant after full adjustment (0.50 [0.22-1.16]). Contrary, in men AVSI was associated with an increased risk to develop type 2 diabetes (1.93 [1.03-3.60]) after full adjustment. Participation in social activities decreased the risk to develop prediabetes and type 2 diabetes in women, (age-adjusted 0.65 [0.46-0.91] and 0.43 [0.24-0.77], respectively), less significant when adjusted for confounders (0.78 [0.54-1.12] and 0.59 [0.31-1.13]). In men a decreased risk was observed for prediabetes (0.59 [0.43-0.82] multi-adjusted model). Being married or living with a partner decreased type 2 diabetes risk only in men (0.57 [0.33-0.97] and 0.61 [0.34-1.08] age-and multi-adjusted models, respectively).Conclusions: Individuals having a social network seemed less likely to develop abnormal glucose regulation. Contradictory to an overall protective pattern of having a social network, high AVSI-index in men increased the risk to develop type 2 diabetes. (C) 2014 Elsevier Ireland Ltd. All rights reserved.