LncTarD: a manually-curated database of experimentally-supported functional lncRNA-target regulations in human diseases
LncTarD: a manually-curated database of experimentally-supported functional lncRNA-target regulations in human diseases
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LncTarD：人类疾病中经实验支持的功能性 lncRNA 目标调控的手动数据库
DOI：
10.1093/nar/gkz985
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发表时间：
2020-01-08
影响因子：
14.9
通讯作者：
Li, Xia
中科院分区：
文献类型：
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作者：
Zhao, Hongying;Shi, Jian;Li, Xia
长链非编码 RNA (lncRNA) 与人类疾病相关。尽管lncRNA与疾病的关联受到了极大的关注，但没有在线存储库可以收集人类疾病中lncRNA介导的调控机制、关键下游靶点以及由疾病相关lncRNA驱动的重要生物学功能。因此，我们开发了LncTarD（http://biocc.hrbmu.edu.cn/LncTarD/或http://bio-bigdata.hrbmu.edu.cn/LncTarD），这是一个手动管理的数据库，提供人类疾病中关键lncRNA靶标调控、lncRNA影响的功能和lncRNA介导的调控机制的综合资源。 LncTarD 提供 (i) 2822 个关键 lncRNA 靶点调控，涉及 475 个 lncRNA 和与 177 种人类疾病相关的 1039 个靶点； (ii) 人类疾病中 1613 个经实验支持的功能调控和 1209 个表达关联； (iii) 人类疾病中疾病相关lncRNA驱动的重要生物学功能； (iv) 负责人类疾病耐药性或敏感性的 lncRNA 靶标调节，以及 (v) 来自 TCGA 的 11 373 例泛癌患者队列的 lncRNA 微阵列、lncRNA 序列数据和转录组数据，以帮助表征这些 lncRNA 靶标调节的功能动态。 LncTarD还提供了友好的用户界面，可以方便地浏览、搜索和下载数据。 LncTarD 将成为进一步了解人类疾病中 lncRNA 失调的功能和分子机制的有用资源平台，这将有助于识别新颖且敏感的生物标志物和治疗靶点。
Long non-coding RNAs (lncRNAs) are associated with human diseases. Although lncRNA-disease associations have received significant attention, no online repository is available to collect lncRNA-mediated regulatory mechanisms, key downstream targets, and important biological functions driven by disease-related lncRNAs in human diseases. We thus developed LncTarD (http://biocc.hrbmu.edu.cn/LncTarD/or http://bio-bigdata.hrbmu.edu.cn/LncTarD), a manually-curated database that provides a comprehensive resource of key lncRNA-target regulations, lncRNA-influenced functions, and lncRNA-mediated regulatory mechanisms in human diseases. LncTarD offers (i) 2822 key lncRNA-target regulations involving 475 lncRNAs and 1039 targets associated with 177 human diseases; (ii) 1613 experimentally-supported functional regulations and 1209 expression associations in human diseases; (iii) important biological functions driven by disease-related lncRNAs in human diseases; (iv) lncRNA-target regulations responsible for drug resistance or sensitivity in human diseases and (v) lncRNA microarray, lncRNA sequence data and transcriptome data of an 11 373 pan-cancer patient cohort from TCGA to help characterize the functional dynamics of these lncRNA-target regulations. LncTarD also provides a user-friendly interface to conveniently browse, search, and download data. LncTarD will be a useful resource platform for the further under-standing of functions and molecular mechanisms of lncRNA deregulation in human disease, which will help to identify novel and sensitive biomarkers and therapeutic targets.