Viruses and salivary gland disease (SGD): lessons from HIV SGD.
Viruses and salivary gland disease (SGD): lessons from HIV SGD.
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DOI：
10.1177/0022034510396882
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发表时间：
2011-04-01
影响因子：
--
通讯作者：
Webster-Cyriaque, J Y
中科院分区：
文献类型：
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作者：
Jeffers, L;Webster-Cyriaque, J Y
病毒感染通常与唾液腺病理学有关。在这里，我们回顾了艾滋病毒相关的唾液腺疾病（HIV-SGD），弥漫性浸润性淋巴细胞增多综合征的标志的发病机制。我们调查的存在和贡献的病毒性疾病的发病机制的唾液腺疾病，特别是艾滋病毒-SGD。我们在HIV-SGD患者的唾液中检测到BK病毒脱落，这与病毒感染和复制一致，表明其在口腔传播中的作用。为了进一步研究BKV在唾液腺中的发病机制，描述了BKV感染的体外模型。通过BKV基因表达和复制测定，颌下腺（HSG）和腮腺（HSY）唾液腺细胞系能够允许BKV感染。对这些数据的分析共同表明，BKV口服传播途径和唾液腺发病机制在HIV-SGD中的潜力。
Viral infections are often associated with salivary gland pathology. Here we review the pathogenesis of HIV-associated salivary gland disease (HIV-SGD), a hallmark of diffuse infiltrative lymphocytosis syndrome. We investigate the presence and contributions of viral diseases to the pathogenesis of salivary gland diseases, particularly HIV-SGD. We have detected BK viral shedding in the saliva of HIV-SGD patients consistent with viral infection and replication, suggesting a role for oral transmission. For further investigation of BKV pathogenesis in salivary glands, an in vitro model of BKV infection is described. Submandibular (HSG) and parotid (HSY) gland salivary cell lines were capable of permissive BKV infection, as determined by BKV gene expression and replication. Analysis of these data collectively suggests the potential for a BKV oral route of transmission and salivary gland pathogenesis within HIV-SGD.