Identifying CDKN3 Gene Expression as a Prognostic Biomarker in Lung Adenocarcinoma via Meta-analysis.
Identifying CDKN3 Gene Expression as a Prognostic Biomarker in Lung Adenocarcinoma via Meta-analysis.
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DOI：
10.4137/cin.s17287
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发表时间：
2015
影响因子：
2
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Zang X;Chen M;Zhou Y;Xiao G;Xie Y;Wang X
肺癌是癌症死亡的主要原因之一，肺癌患者的存活率极低。最近的研究表明，基因CDKN 3与肿瘤形成有关，但在文献中，关于它是否参与癌症进展或相反，肿瘤抑制存在严重争议。在这项研究中，我们使用肺癌浏览器（LCE; http：//qbrc.swmed.edu/lce/）中的数据集研究了肺腺癌（ADC）和鳞状细胞癌（SCC）中CDKN 3的表达及其与预后的关系。我们发现，与正常组织相比，CDKN 3在ADC和SCC中上调。Meta分析进一步验证了CDKN 3在SCC中的表达水平高于ADC（coefficient = 2.09，95% CI = 1.50-2.67，P < 0.0001）。此外，基于对CDKN 3预后价值的荟萃分析，我们发现CDKN 3高表达与ADC的生存结局较差相关（HR = 1.65，95% CI = 1.39-1.96，P < 0.0001），但与SCC无关（HR = 1.10，95% CI = 0.84-1.44，P = 0.494）。我们的研究结果表明，CDKN 3可能是ADC的预后标志物，但详细的机制尚未被揭示。
Lung cancer is among the major causes of cancer deaths, and the survival rate of lung cancer patients is extremely low. Recent studies have demonstrated that the gene CDKN3 is related to neoplasia, but in the literature severe controversy exists over whether it is involved in cancer progression or, conversely, tumor inhibition. In this study, we investigated the expression of CDKN3 and its association with prognosis in lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) using datasets in Lung Cancer Explorer (LCE; http://qbrc.swmed.edu/lce/). We found that CDKN3 was up-regulated in ADC and SCC compared to normal tissues. We also found that CDKN3 was expressed at a higher level in SCC than in ADC, which was further validated through meta-analysis (coefficient = 2.09, 95% CI = 1.50–2.67, P < 0.0001). In addition, based on meta-analysis for the prognostic value of CDKN3, we found that higher CDKN3 expression was associated with poorer survival outcomes in ADC (HR = 1.65, 95% CI = 1.39–1.96, P < 0.0001), but not in SCC (HR = 1.10, 95% CI = 0.84–1.44, P = 0.494). Our findings indicate that CDKN3 may be a prognostic marker in ADC, though the detailed mechanism is yet to be revealed.