MODULATION OF NEONATAL RAT HYPOGLOSSAL MOTONEURON EXCITABILITY BY SEROTONIN
MODULATION OF NEONATAL RAT HYPOGLOSSAL MOTONEURON EXCITABILITY BY SEROTONIN
复制标题
DOI：
10.1016/0304-3940(92)90257-8
复制
发表时间：
1992-08-31
影响因子：
2.5
通讯作者：
VIANA, F
中科院分区：
文献类型：
--
作者：
BERGER, AJ;BAYLISS, DA;VIANA, F
用两种离体脑片研究了5-羟色胺（5-HT）对新生大鼠舌下神经运动神经元（HMs）的影响。5-羟色胺引起可逆去极化或产生内向电流（I5-HT）在每个测试的细胞。突触阻断后，I5-HT持续存在。在大多数测试的细胞中，I5-HT的大小与膜电位（-50到-120 mV）无关，并且5-HT对输入电阻或斜率电导几乎没有影响。此外，5-HT还能显著降低放电后中时程后超极化的幅度。这种减少可能导致的斜率增加的关系描述的稳态发射频率响应注入电流（f-I）中观察到的5-HT的存在下。因此，5-HT通过至少两种不同的突触后机制增加新生儿HM的兴奋性。
The effects of 5-HT on neonatal rat hypoglossal motoneurons (HMs) were studied in two in vitro slice preparations. Serotonin caused either reversible depolarization or the generation of an inward current (I5-HT) in every cell tested. I5-HT persisted after synaptic blockade. In most of the cells tested, the magnitude of I5-HT was independent of membrane potential (-50 to -120 mV), and 5-HT had little effect on input resistance or slope conductance. In addition, 5-HT significantly reduced the amplitude of the post-spike medium-duration afterhyperpolarization. This reduction probably contributed to the resulting increase in the slope of the relationship describing the steady-state firing frequency response to injected current (f-I) observed in the presence of 5-HT. Thus, 5-HT increases the excitability of neonatal HMs via at least two different postsynaptic mechanisms.