Integrating genome-based informatics to modernize global disease monitoring, information sharing, and response.
Integrating genome-based informatics to modernize global disease monitoring, information sharing, and response.
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DOI：
10.3201/eid/1811.120453
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发表时间：
2012-11
影响因子：
11.8
通讯作者：
Schlundt J
中科院分区：
文献类型：
--
作者：
Aarestrup FM;Brown EW;Detter C;Gerner-Smidt P;Gilmour MW;Harmsen D;Hendriksen RS;Hewson R;Heymann DL;Johansson K;Ijaz K;Keim PS;Koopmans M;Kroneman A;Lo Fo Wong D;Lund O;Palm D;Sawanpanyalert P;Sobel J;Schlundt J
基因组技术的迅速发展为提高临床和公共卫生实验室调查的质量和速度以及降低其成本带来了巨大希望。最新一代的基因组DNA测序仪可以提供有关致病微生物的非常详细和可靠的信息，在不久的将来，这些技术将适用于国家、地区和全球公共卫生实验室的常规使用。随着仪器的进一步改进，这些下一代或第三代测序仪很可能取代传统的基于培养和分子分型的方法，以提供即时临床诊断和其他重要信息，从而更快更好地治疗患者。如果所有临床和公共卫生实验室都能免费共享信息，这些基因组工具就能产生一个全球性的病原体基因组数据库链接系统，确保更有效地检测、预防和控制世界各地的地方病、新发疾病和其他传染病爆发。
The rapid advancement of genome technologies holds great promise for improving the quality and speed of clinical and public health laboratory investigations and for decreasing their cost. The latest generation of genome DNA sequencers can provide highly detailed and robust information on disease-causing microbes, and in the near future these technologies will be suitable for routine use in national, regional, and global public health laboratories. With additional improvements in instrumentation, these next- or third-generation sequencers are likely to replace conventional culture-based and molecular typing methods to provide point-of-care clinical diagnosis and other essential information for quicker and better treatment of patients. Provided there is free-sharing of information by all clinical and public health laboratories, these genomic tools could spawn a global system of linked databases of pathogen genomes that would ensure more efficient detection, prevention, and control of endemic, emerging, and other infectious disease outbreaks worldwide.