Is relative leg length a biomarker of childhood nutrition? Long-term follow-up of the Hyderabad Nutrition Trial
Is relative leg length a biomarker of childhood nutrition? Long-term follow-up of the Hyderabad Nutrition Trial
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DOI：
10.1093/ije/dyr074
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发表时间：
2011-08-01
影响因子：
7.7
通讯作者：
Ben-Shlomo, Yoav
中科院分区：
文献类型：
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作者：
Kinra, Sanjay;Sarma, K. V. Rameshwar;Ben-Shlomo, Yoav
方法在社区营养补充试验中，选择邻近行政区划的村庄作为干预组(n=15)和对照组(n=14)。在干预村，孕妇及其子女每天补充平衡的蛋白质-卡路里(2.51MJ，20g蛋白质)，直到6岁。结果共调查了1165名13-18岁的青少年(干预：654名，占试验参与者的49%；对照组：511名，占试验参与者的41%)。补充的儿童身高增加了10 mm[95%可信区间(CI)：1.4到18.7 mm]，但几乎所有的增长都是在躯干长度(9 mm，95%CI：2.6到15.4 mm)。年龄和性别调整后的β系数分别为0.26(95%CI：0.11~0.42)、0.08(95%CI：-0.03~0.19)和0.03(95%CI：-0.08~0.15)。结论在本次营养不良人群的营养补充试验中，未能证实相对腿长是儿童营养的生物标志物。另一种解释可能是报道的儿童状况和相对腿长之间的联系。
Methods In a community trial of nutritional supplementation, villages from adjacent administrative areas were selected to serve as intervention (n = 15) and control (n = 14) arms. In the intervention villages, balanced protein-calorie supplementation (2.51 MJ, 20 g protein) was offered daily to pregnant women and their offspring until the age of 6 years. Children born in the trial were re-examined 15 years later to assess components of height.Results A total of 1165 adolescents (intervention: 654, 49% of trial participants; control: 511, 41% of trial participants) aged 13-18 years were examined. Supplemented children were 10 mm taller [95% confidence interval (CI): 1.4 to 18.7 mm], but almost all of the increase was in trunk length (9 mm, 95% CI: 2.6 to 15.4 mm). The age- and gender-adjusted beta-coefficients for the association of nutritional supplementation with relative trunk, leg and lower leg lengths (expressed as standard deviation scores) were 0.26 (95% CI: 0.11 to 0.42), 0.08 (95% CI: -0.03 to 0.19) and 0.03 (95% CI: -0.08 to 0.15) respectively, thereby unsupportive of cephalocaudal gradient in growth.Conclusions In this nutritional supplementation trial in an undernourished population, we were unable to confirm relative leg length as a biomarker of childhood nutrition. Alternative explanations may underlie the reported associations between childhood conditions and relative leg length.