Impairments in conditioned stimulus processing and conditioned responding after combined selective removal of hippocampal and neocortical cholinergic input
Impairments in conditioned stimulus processing and conditioned responding after combined selective removal of hippocampal and neocortical cholinergic input
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DOI：
10.1037/0735-7044.113.3.486
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发表时间：
1999-06-01
影响因子：
1.9
通讯作者：
Gallagher, M
中科院分区：
文献类型：
--
作者：
Baxter, MG;Bucci, DJ;Gallagher, M
以往的研究表明，条件刺激的注意加工过程受基底前脑胆碱能系统的调节。在这些研究中，破坏BF神经支配的新皮层干扰增强CS处理，和破坏BF神经支配的海马阻止CS处理减少。在目前的实验中，192 IgG-皂草素病变的海马和新皮层胆碱能输入的大鼠的性能进行了检查。这些合并病变破坏了CS处理的增强和减少。损伤大鼠也表现出更多的条件反射的一般性障碍。这些结果表明，虽然增加和减少注意力处理的神经系统可能在很大程度上是独立的，海马和新皮质胆碱能输入的联合损失可能会产生行为障碍，单独损伤后不明显。
Previous studies indicated that changes in attentional processing of conditioned stimuli (CSs) are regulated by the basal forebrain (BF) cholinergic system. In those studies, destruction of BF innervation of the neocortex interfered with enhancements in CS processing, and destruction of BF innervation of the hippocampus prevented reductions in CS processing. In the current experiments, the performance of rats with 192 IgG-saporin lesions of both hippocampal and neocortical cholinergic input was examined. These combined lesions disrupted both enhancements and reductions in CS processing. Lesioned rats also showed more general impairments in conditioned responding. These results indicate that, although the neural systems for increasing and decreasing attentional processing may be largely independent, combined loss of hippocampal and neocortical cholinergic input may produce behavioral impairments that are not apparent after either lesion alone.