Activity Regulates the Incidence of Heteronymous Sensory-Motor Connections.
Activity Regulates the Incidence of Heteronymous Sensory-Motor Connections.
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DOI：
10.1016/j.neuron.2015.05.045
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发表时间：
2015-07-01
期刊：
影响因子：
16.2
通讯作者：
Jessell TM
中科院分区：
文献类型：
--
作者：
Mendelsohn AI;Simon CM;Abbott LF;Mentis GZ;Jessell TM
脊髓感觉-运动回路的构建包括选择合适的突触伙伴和分配准确的突触输入密度。当周围感觉激活被阻断时，脊髓感觉-运动选择性的许多方面似乎被保留下来，这导致了一种观点，即感觉-运动回路是以一种独立于活动的方式组装的。然而，目前尚不清楚依赖活动的精炼是否在感觉传入和具有协同生物力学功能的运动池之间建立联系中发挥作用。我们在这里表明，从基因上取消中枢感觉-运动神经传递会导致这种“异名”连接的数量和密度有选择地增加，而感觉-运动连接的其他方面则得到保留。依赖于棘波时序的突触细化是活动阻断后观察到的连接性变化的一种可能机制。因此，我们的发现揭示了感觉活动在建立有模式的单突触感觉-运动连接中确实具有有限和选择性的作用。
The construction of spinal sensory-motor circuits involves the selection of appropriate synaptic partners and the allocation of precise synaptic input densities. Many aspects of spinal sensory-motor selectivity appear to be preserved when peripheral sensory activation is blocked, which has led to a view that sensory-motor circuits are assembled in an activity-independent manner. Yet it remains unclear whether activity-dependent refinement has a role in the establishment of connections between sensory afferents and those motor pools that have synergistic biomechanical functions. We show here that genetically abolishing central sensory-motor neurotransmission leads to a selective enhancement in the number and density of such “heteronymous” connections, whereas other aspects of sensory-motor connectivity are preserved. Spike-timing dependent synaptic refinement represents one possible mechanism for the changes in connectivity observed after activity blockade. Our findings therefore reveal that sensory activity does have a limited and selective role in the establishment of patterned monosynaptic sensory-motor connections.