Introduction to In Silico Modeling to Study ROS Dynamics.

Introduction to In Silico Modeling to Study ROS Dynamics.
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用于研究 ROS 动力学的计算机建模简介

DOI:
10.1007/978-1-0716-0896-8_1
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发表时间:
2021
影响因子:
--
通讯作者:
Schleicher
Schleicher
中科院分区:
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文献类型:
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作者:
Schleicher

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这本书的章节是为生物学家起草的,他们在ROS生物学方面有实验经验,但在建模领域是新手。我们首先对生物学中的计算建模进行一般介绍,并概述适合初学者的软件工具。本章包括对计算模型的介绍,特别关注ROS动力学的模拟。随后将提供一个循序渐进的教程,为所有相关模型开发流程提供指导。这一行动过程提供了一种可理解的方式来理解计算模型的好处,并获得必要的知识来建立自己的基于方程式的小模型。可以在没有任何特殊编程专业知识或深入的技术和数学知识的情况下创建小型模型。之后,在最后一节中,提供了陷阱、挑战和限制的简短概述,并结合了进一步阅读的建议,以改进和扩展生物学家的建模技能。
This book chapter is drafted for biologists with experimental experiences in ROS biology but being newcomers in the field of modeling. We start with a general introduction about computational modeling in biology and an overview of software tools suitable for beginners. This chapter encompasses an introduction to computational models with special focus on simulation of ROS dynamics. A step-by-step tutorial follows providing guidance for all relevant model development processes. This course of action gives a comprehensible way to understand the benefits of computational models and to gain the necessary knowledge to build own small equation-based models. Small models can be created without any special programming expertise or in-depth technical and mathematical knowledge. Afterward in the final section, a short overview of pitfalls, challenges, and limitations is provided, combined with suggestions for further reading to improve and expand modeling skills of biologists.
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