HLA class II allele frequencies in the Lebanese population
HLA class II allele frequencies in the Lebanese population
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DOI：
10.1016/j.gene.2012.06.063
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发表时间：
2012-09-15
期刊：
影响因子：
3.5
通讯作者：
Mahfouz, Rami A. R.
中科院分区：
文献类型：
--
作者：
Khansa, Sara;Hoteit, Rouba;Mahfouz, Rami A. R.
目的：人类白细胞抗原系统作为最具多态性的遗传系统之一，分为I类（HLA-A、HLA-B和HLA-C）和II类（HLA-DP、-DQ和-DR）。这项研究是第一个也是最大的同类研究，以描述分布的HLA-DQB 1和HLA-DRB 1等位基因在黎巴嫩和region.Methods：分别为560和563名黎巴嫩人提到的HLA分型和可能的骨髓/肾脏捐赠进行了测试HLA-DQB 1和HLA-DRB 1等位基因使用聚合酶链反应/序列特异性引发（PCR-SSP）方法。我们的数据与几个人群的数据进行了比较，在黎巴嫩、约旦、巴林、沙特、科威特、突尼斯、韩国、日本、泰国、爱尔兰、保加利亚和波兰人群之间发现了有趣的共同发现。结论：这些关于黎巴嫩人口的数据将有助于未来的研究人员研究HLA-DQB 1和HLA-1之间的关系。DRB 1等位基因与黎巴嫩人口中的主要和常见疾病，并将添加到现有的国际文献与这些基因座。同时也为我国今后的骨髓登记工作提供参考。我们还回顾了文献中描述的HLA-DRB 1和-DQB 1基因座与不同疾病实体之间的关联。(C)2012爱思唯尔有限公司版权所有。
Aims: Being one of the most polymorphic genetic systems, the Human Leukocyte Antigen system is divided into class I (HLA-A, HLA-B and HLA-C) and class II (HLA-DP, -DQ and -DR). This study is the first and largest of its kind to describe the distribution of HLA-DQB1 and HLA-DRB1 alleles in Lebanon and the region.Methods: Respectively, 560 and 563 Lebanese individuals referred for HLA typing and possible bone marrow/kidney donation were tested for HLA-DQB1 and HIA-DRB1 alleles using the polymerase chain reaction/sequence specific priming (PCR-SSP) method.Results: Our data were compared to that of several populations with interesting common findings between the Lebanese, Jordanian, Bahraini, Saudi, Kuwaiti, Tunisian, Korean, Japanese, Thai, Irish, Bulgarian and Polish populations.Conclusion: These data about the Lebanese population are going to aid future researchers to study the relation of HLA-DQB1 and HLA-DRB1 alleles with major and common diseases in the Lebanese population and will add to the available international literature associated with these loci. In addition it will serve as a reference for the future national bone marrow registry program in our country. we also reviewed the literature for the described association between HLA-DRB1 and -DQB1 loci and different disease entities. (C) 2012 Elsevier B.V. All rights reserved.