Evaluation and comparison of three mobilization methods for the collection of granulocytes

Evaluation and comparison of three mobilization methods for the collection of granulocytes
复制标题

三种粒细胞收集动员方法的评价和比较

DOI：
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发表时间：
1998
期刊：
Transfusion
影响因子：
2.9
通讯作者：
Emil J. Freireich
Emil J. Freireich
中科院分区：
医学3区
文献类型：
--
作者：
D. Jendiroba;Benjamin Lichtiger;E. Anaissie;V. Reddy;S. O’Brien;H. Kantarjian;Emil J. Freireich

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背景：癌症化疗方案已变得更加有效和清髓性。因此，机会性感染导致的发病率和死亡率已成为一个重大挑战。因此，提供足够剂量的活性粒细胞已成为规避该问题的重要方法。一个收集治疗数量的细胞与最小的供体毒性的时间表尚未建立。
BACKGROUND: Cancer chemotherapeutic regimens have become more potent and myeloablative. As a consequence, morbidity and mortality due to opportunistic infections have become a major challenge. The provision of adequate doses of viable granulocytes has thus become an important approach for circumventing the problem. A schedule for collecting therapeutic numbers of cells with minimal donor toxicity has yet to be established.