Deterministic patterns in cell motility
Deterministic patterns in cell motility
复制标题
DOI：
10.1038/nphys3836
复制
发表时间：
2016-12-01
期刊：
影响因子：
19.6
通讯作者：
Gov, Nir S.
中科院分区：
文献类型：
--
作者：
Lavi, Ido;Piel, Matthieu;Gov, Nir S.
细胞迁移路径通常被描述为随机行走，与内在和外在噪声有关。然而，复杂的细胞运动不仅与这种波动有关，而且往往是由潜在的机制决定的。细胞运动是由肌动蛋白和肌凝蛋白驱动的，这两种分子成分产生收缩力。其他细胞功能利用相同的成分，因此，将与迁移装置竞争。在这里，我们提出了这样一个竞争系统的物理模型，即树突状细胞，其抗原捕获功能和迁移能力是由肌球蛋白II耦合的。该模型预测，这种耦合会引起动态不稳定性，从而细胞通过Hopf分岔从持续迁移切换到单向自振荡。细胞可以通过同斜分叉切换到周期性极性反转。这些预测的动态机制的特点是强大的特征，我们通过长时间尺度和距离的树突状细胞的体外轨迹识别。我们期望在其他迁移细胞类型中对有限资源的竞争可以导致类似的确定性迁移模式。
Cell migration paths are generally described as random walks, associated with both intrinsic and extrinsic noise. However, complex cell locomotion is not merely related to such fluctuations, but is often determined by the underlying machinery. Cell motility is driven mechanically by actin and myosin, two molecular components that generate contractile forces. Other cell functions make use of the same components and, therefore, will compete with the migratory apparatus. Here, we propose a physical model of such a competitive system, namely dendritic cells whose antigen capture function and migratory ability are coupled by myosin II. The model predicts that this coupling gives rise to a dynamic instability, whereby cells switch from persistent migration to unidirectional self-oscillation, through a Hopf bifurcation. Cells can then switch to periodic polarity reversals through a homoclinic bifurcation. These predicted dynamic regimes are characterized by robust features that we identify through in vitro trajectories of dendritic cells over long timescales and distances. We expect that competition for limited resources in other migrating cell types can lead to similar deterministic migration modes.