Association between APOE ε2/ε3/ε4 polymorphism and disability severity in a national long-term care survey sample
Association between APOE ε2/ε3/ε4 polymorphism and disability severity in a national long-term care survey sample
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DOI：
10.1093/ageing/afn003
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发表时间：
2008-05-01
期刊：
影响因子：
6.7
通讯作者：
Yashin, Anatoli I.
中科院分区：
文献类型：
--
作者：
Kulminski, Alexander;Ukraintseva, Svetlana V.;Yashin, Anatoli I.
背景资料：早期的研究报道了载脂蛋白E（APOE）基因多态性与残疾的关系，这一发现存在争议。（工具性）日常生活活动[（I）ADL]和死亡率。设计：基于人群的1999年美国老年人（65岁以上）国家长期护理调查（NLTCS）。参与者：方法：采用APOE基因座3个常见等位基因的6种基因型，（1992年、1993年和1994年）与残疾指数或死亡率的关系进行了检验。在男性中，APOE β 3/β 3基因型显著降低IADL残疾的优势比（OR）[OR = 0.48; 95%置信区间（CI）0.31-0.76]，而在女性中未显示相关性。1994/1994年女性携带者ADL残疾的OR为0.19（CI 0.04-0.99）。男性IADL残疾的发生率与基因型无关（OR = 2.33，CI 1.28-4.25）。未发现APOE多态性与死亡率之间存在显着相关性。令人惊讶的观察结果是，epsilon 4/epsilon 4女性携带者患ADL残疾的机会比非epsilon 4/epsilon 4携带者低5.3倍。结论：APOE基因多态性与残疾的相关性和与死亡率的缺乏相关性支持了这样一种观点，即APOE基因的作用可能作为虚弱的调节剂比中心blog
Background: early studies reported controversial findings on association of apolipoprotein E (APOE) polymorphism with disability.Objective: to analyse sex-specific associations of APOE genotypes with impairments in (instrumental) activities of daily living [(I)ADL] and mortality.Design: population-based 1999 National Long Term Care Survey (NLTCS) of the US older (65+) individuals.Participants: genetic data are available for 1,805 individuals.Methods: each of six genotypes of three common alleles of the APOE locus (epsilon 2, epsilon 3 and epsilon 4) was tested on the association with a disability index or mortality.Results: APOE epsilon 3/epsilon 3 genotype significantly decreases odds ratio (OR) for IADL disability in males [OR = 0.48; 95% Confidence Interval (CI) 0.31-0.76] while it exhibits no association in females. The OR for ADL disability is 0.19 (CI 0.04-0.99) for epsilon 4/epsilon 4 female carriers. The epsilon 2/epsilon 3 genotype increases the chances of IADL disability for males (OR = 2.33; CI 1.28-4.25). No significant association between APOE polymorphism and mortality was found. A surprising observation was that epsilon 4/epsilon 4 female carriers have a 5.3 times lower chance of having ADL disability than non-epsilon 4/epsilon 4-carriers.Conclusions: association of the APOE polymorphism with disability and lack of association with mortality support the view that APOE gene actions may be more significant as modulators of frailty than of longevity.