GlycA, a novel marker of inflammation, is elevated in systemic lupus erythematosus.
GlycA, a novel marker of inflammation, is elevated in systemic lupus erythematosus.
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DOI：
10.1177/0961203315617842
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发表时间：
2016-03
期刊：
影响因子：
2.6
通讯作者：
Stein CM
中科院分区：
文献类型：
--
作者：
Chung CP;Ormseth MJ;Connelly MA;Oeser A;Solus JF;Otvos JD;Raggi P;Stein CM
GlycA是核磁共振检测到的一种新的全身炎症标志物。在普通人群中，GlycA与C-反应蛋白(CRP)等炎症标记物相关，并与冠心病和糖尿病有关。GlycA在系统性红斑狼疮(SLE)患者中的作用尚未确定。因此，我们验证了这一假设，即SLE患者的GlycA浓度升高，并与其他炎症和冠状动脉粥样硬化标志物相关。我们比较了116名SLE患者和84名在年龄、性别和种族方面频率匹配的对照受试者的核磁共振检测到的GlycA浓度。计算SLE疾病活动指数(SLEDAI)和SLE联合诊所损害指数(SLICC)。测量了急性期反应物、一组细胞因子和一组脂类。电子束计算机断层扫描(EBCT)被用来量化冠状动脉钙化，这是冠状动脉粥样硬化的一种衡量标准。系统性红斑狼疮患者的血糖浓度[398(350-445)]明显高于对照组[339(299-391)]，P<；0.001。在系统性红斑狼疮患者中，GlycA浓度与血沉(Rho=0.0023.43)、C反应蛋白(Rho=0.5 9)、E-选择素(Rho=0.2 8)、细胞间黏附分子-1(Rho=0.30)、甘油三酯(Rho=0.45)显著相关(P均<0.0 5)，但与肌酐、SLEDAI、SLICC或冠状动脉钙化积分无关。SLE患者的GlycA浓度高于对照组，且与炎症标志物相关，但与SLE疾病活动性或慢性化评分或冠状动脉钙化无关。
GlycA is a novel marker of systemic inflammation detected by nuclear magnetic resonance spectroscopy (NMR). In the general population, GlycA is correlated with inflammatory markers such as C-reactive protein (CRP) and associated with coronary heart disease and diabetes. The utility of GlycA in patients with systemic lupus erythematosus (SLE) has not been defined. Therefore, we tested the hypothesis that GlycA concentrations are elevated in patients with SLE and associated with other markers of inflammation and coronary atherosclerosis. We compared concentrations of GlycA, detected by NMR, in 116 patients with SLE and 84 control subjects frequency-matched for age, sex, and race. SLE disease activity index (SLEDAI) and the SLE Collaborating Clinics damage index (SLICC) were calculated. Acute phase reactants, a panel of cytokines, and a lipid panel were measured. Electron beam computer tomography (EBCT) was used to quantify coronary artery calcification, a measure of coronary artery atherosclerosis. Patients with SLE had higher concentrations of GlycA [398 (350–445)] than control subjects [339 (299–391)] µmol/L, p<0.001. In patients with SLE, concentrations of GlycA were significantly associated with sedimentation rate (rho=0.43), C-reactive protein (rho=0.59), e-selectin (rho=0.28), intracellular adhesion molecule-1 (rho=0.30), triglycerides (rho=0.45), all p<0.0023 to account for multiple comparisons, but not with creatinine, SLEDAI, SLICC, or coronary calcium scores. Concentrations of GlycA are higher in patients with SLE than control subjects and associated with markers of inflammation but not with SLE disease activity or chronicity scores or coronary artery calcification.