Neurochemical alterations produced by daily nicotine exposure in periadolescent vs. adult male rats
Neurochemical alterations produced by daily nicotine exposure in periadolescent vs. adult male rats
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DOI：
10.1016/j.ejphar.2004.08.039
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发表时间：
2004-10-11
影响因子：
5
通讯作者：
Izenwasser, S
中科院分区：
文献类型：
--
作者：
Collins, SL;Wade, D;Izenwasser, S
与成年大鼠相比，尼古丁长期给药可不同程度地改变青春期大鼠的行为。然而，目前尚不清楚尼古丁对青少年与成人之间相互作用的神经化学途径的影响是否不同。在当前研究中，在青春期前后与成年雄性大鼠的尾状核和延髓核中检查了尼古丁给药7天对烟碱、多巴胺能和多巴胺能神经化学的影响。尼古丁治疗增加多巴胺转运体密度和减少5-羟色胺转运体密度在青春期大鼠。尼古丁预处理的青春期大鼠的烟碱乙酰胆碱受体密度或多巴胺D1或D2受体密度没有变化。在用尼古丁预处理的成年大鼠中，烟碱乙酰胆碱密度增加，但多巴胺转运蛋白、多巴胺D1或D2受体或5-羟色胺转运蛋白密度没有变化。总的来说，这些发现表明，青春期大鼠对尼古丁的神经化学适应不同于成年大鼠。这些变化可以解释，至少部分，慢性尼古丁在成年和青春期雄性大鼠的行为差异的影响。(C)2004 Elsevier B. V.保留所有权利。
Chronic treatment with nicotine differentially alters behavior in adolescent rats compared to adult rats. It is not known, however whether the effects of nicotine on the neurochemical pathways with which it interacts differ in adolescents vs. adults. In the current study, the effects of a 7-day treatment with nicotine on nicotinic, dopaminergic, and serotonergic neurochemistry were examined in the caudate put men and nucleus accumbens in periadolescent vs. adult male rats. Nicotine treatment increased dopamine transporter densities and decreased serotonin transporter densities in periadolescent rats. There was no change in nicotinic acetylcholine receptor densities or dopamine D1 or D2 receptor densities in nicotine-pretreated periadolescent rats. In adult rats pretreated with nicotine, there was an increase in nicotinic acetylcholine densities, but no change in dopamine transporter, dopamine D1 or D2 receptor, or serotonin transporter densities. Overall, these findings show that periadolescent rats have neurochemical adaptations to nicotine different from adult rats. These alterations may explain, at least in part, the differential behavioral effects of chronic nicotine in adult and adolescent male rats. (C) 2004 Elsevier B.V. All rights reserved.