Early weight bearing of porous HA/TCP (60/40) ceramics in vivo:: A longitudinal study in a segmental bone defect model of rabbit
Early weight bearing of porous HA/TCP (60/40) ceramics in vivo:: A longitudinal study in a segmental bone defect model of rabbit
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DOI：
10.1016/j.actbio.2007.04.004
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发表时间：
2007-11-01
影响因子：
9.7
通讯作者：
Korkusuz, Feza
中科院分区：
文献类型：
--
作者：
Balcik, Cenk;Tokdemir, Turgut;Korkusuz, Feza
多孔羟基磷灰石（HA）和HA/磷酸三钙（TCP）（60/40）陶瓷是一种很有前途的硬组织修复材料。然而，这些材料在负重条件下的力学性能还没有得到准确的测定。本研究采用新研制的HA和HA/TCP（60/40）陶瓷材料髓内固定兔节段性骨缺损。评估早期放射学、组织学、密度学和生物力学变化。HA/TCP（60/40）陶瓷的愈合和与骨结合的平均放射学分级高于纯HA陶瓷，但差异无统计学意义。在骨基质向陶瓷孔内生长的组织学评价支持下，两种植入陶瓷的密度都随着时间的推移而提高，而骨-陶瓷界面的密度则逐渐降低。弯曲共振频率和三点弯曲强度增加，表明在早期关键时间间隔内机械稳定性增加，植入物和/或骨-植入物界面故障频繁发生。由此可见，HA和HA/TCP（60/40）陶瓷在治疗负重节段性骨缺损方面应用有限，但在种植初期并未失败。(C) 2007材料学报Elsevier Ltd.出版。版权所有。
Porous interconnected hydroxyapatite (HA) and HA/tricalcium phosphate (TCP) (60/40) ceramics are promising materials for hard tissue repair. However, the mechanical properties of these materials have not been accurately determined under weight-bearing conditions. In this study, newly developed HA and HA/TCP (60/40) ceramics were used with intramedullary fixation in segmental bone defects of rabbits. Early radiological, histological, densitometric and biomechanical changes were evaluated. The mean radiological grade of healing and bonding to bone was higher in HA/TCP (60/40) ceramics than that of pure HA ceramics but the difference was not statistically significant. The densities of both implanted ceramics improved with time, supported by the histological evaluation of bone matrix ingrowth into ceramic pores, whereas the densities at the bone-ceramic interface decreased gradually. Flexural resonant frequencies and three-point bending strength increased, revealing an increase in mechanical stability during this early critical time interval where implant and/or bone-implant interface failures occur frequently. It can be concluded that both HA and HA/TCP (60/40) ceramics have a limited application in the treatment of load-bearing segmental bone defects but did not fail at the early stages of implantation. (C) 2007 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.