The DNA content of some mammalian cells measured by flow cytometry and its influence on radiation sensitivity.
The DNA content of some mammalian cells measured by flow cytometry and its influence on radiation sensitivity.
复制标题
流式细胞仪测定的一些哺乳动物细胞的DNA含量及其对辐射敏感性的影响。
DOI：
--
复制
发表时间：
1990
影响因子：
2.6
通讯作者：
H. Dertinger
中科院分区：
文献类型：
--
作者：
W. Sontag;G. Knedlitschek;K. Weibezahn;H. Dertinger
用流式细胞仪测定9种哺乳动物细胞系的DNA含量。利用本实验室和其他实验室的放射生物学数据，当DNA质量与X射线、α粒子和重离子的1/D 0之间的相关性被绘制在双对数尺度上时，就可以建立起来。回归线的斜率分别为0.65（X射线）、0.64（α粒子）和0.74（重离子）。DNA含量和平均灭活剂量之间存在类似的相关性。接近2/3的相当均匀的斜率表明，放射敏感性可能取决于敏感靶点（细胞核）的表面积，表明细胞核内放射敏感位点可能分布不均匀。
The DNA content of nine mammalian cell lines was determined by flow cytometry. Using radiobiological data from this and other laboratories a correlation between DNA mass and 1/D0 for X-rays, alpha-particles, and heavy ions could be established when the quantities were plotted on a log-log scale. The slopes of the regression lines amounted to 0.65 (X-rays), 0.64 (alpha-particles) and 0.74 (heavy ions). A similar correlation was found between DNA content and mean inactivation dose. The rather uniform slopes close to 2/3 suggest that radiosensitivity may depend on the surface area of the sensitive target, (cell nucleus) indicating a possible non-uniform distribution of radiosensitive sites within the nucleus.
影响因子：
3.4
作者：
CURTIS, SB
通讯作者：
CURTIS, SB
高温增强具有临床意义的 X 射线剂量对细胞存活、DNA 损伤和 DNA 修复的影响。
影响因子：
3.4
作者：
Bowden,GT;Kasunic,MD
通讯作者：
Kasunic,MD