Genetic regulation of egg and embryo survival.
Genetic regulation of egg and embryo survival.
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卵子和胚胎存活的遗传调控。
DOI：
10.1093/humrep/13.suppl_3.178
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Brenner,CA
中科院分区：
文献类型：
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作者：
Warner,CM;Cao,W;Exley,GE;McElhinny,AS;Alikani,M;Cohen,J;Scott,RT;Brenner,CA
在小鼠和人类中，15-50%的胚胎在植入前死亡，其机制在很大程度上是未知的。两个主要标准预测植入前胚胎质量，发育速度和破碎程度。我们回顾了这两个标准都有遗传基础的证据。发育速度和随后的胚胎存活率是由我们在小鼠中发现的一种基因Ped控制的。虽然在寻找人类的mousePedgene同源物方面取得了进展，但尚未确定。在小鼠和人类胚胎中观察到的片段化可能是细胞凋亡的结果。我们分析了两个调控细胞凋亡的基因bcl-2和bax的转录，发现这两个基因在小鼠和人类植入前胚胎中都有转录。总体而言，本文回顾的文献和提出的新数据支持植入前卵子和胚胎存活存在遗传基础的概念。
In both mice and humans, 15–50% of embryos die during the preimplantation period from mechanisms that are largely unknown. Two major criteria predict preimplantation embryo quality, the rate of development and the degree of fragmentation. We review evidence that both of these criteria have a genetic basis. Rate of development and subsequent embryo survival are controlled by a gene,Ped, we discovered in the mouse. Although progress is being made in the search for the human homologue of the mousePedgene, it has not yet been identified. Fragmentation, observed in both mouse and human embryos, is probably the result of apoptosis. We analysed transcription of two genes that regulate apoptosis,bcl-2 andbax, and found that both are transcribed in mouse and human preimplantation embryos. Overall, the literature reviewed and new data presented in this paper support the concept that there is a genetic basis for preimplantation egg and embryo survival.