Expression of Serotonin and its 5-HT1A Receptor in Canine Cutaneous Mast Cell Tumours
Expression of Serotonin and its 5-HT1A Receptor in Canine Cutaneous Mast Cell Tumours
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DOI：
10.1016/j.jcpa.2008.08.002
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发表时间：
2009-08-01
影响因子：
0.8
通讯作者：
Nordlind, K.
中科院分区：
文献类型：
--
作者：
Froberg, G. Kastengren;Lindberg, R.;Nordlind, K.
据报道，许多不同动物的肥大细胞含有5-羟色胺(5-羟色胺；5-羟色胺)，这是一种能够发挥多种复杂作用的单胺，可能包括对肿瘤生长的影响。以往有限的研究表明，正常或肿瘤犬的肥大细胞不表达5-羟色胺。本研究用免疫组织化学方法检测了Patnaik组织学分级为I~III级的犬皮肤肥大细胞瘤(MCT)中5-羟色胺及其受体5-HT1a的表达。测定阳性细胞的比例和单个细胞的标记强度。非肿瘤性真皮肥大细胞和肿瘤性肥大细胞均表达5-羟色胺及其受体。肿瘤肥大细胞表达5-羟色胺多于5-羟色胺受体。低分化肿瘤中这两种分子的表达较少，但病变周边分化较好的肥大细胞有更一致的5-羟色胺表达。5-羟色胺和5-HT1a受体可能参与了犬MCT的分化以及与这些肿瘤相关的微血管并发症。(C)2008爱思唯尔有限公司。保留所有权利。
Mast cells of a number of different animal species have been reported to contain serotonin (5-hydroxytryptamine; 5-HT), a monoamine capable of numerous and complex actions, which may include an impact on tumour growth. Limited previous studies have suggested that normal or neoplastic canine mast cells do not express 5-HT. In the present study, canine cutaneous mast cell tumours (MCTs) of Patnaik histological grades I-III were investigated immunohistochemically for expression of 5-HT and its receptor (R) 5-HT1A. The proportion of positively labelled cells and the intensity of labelling of individual cells were determined. Both 5-HT and the 5-HT1A receptor were expressed by non-neoplastic dermal mast cells and neoplastic mast cells. More neoplastic mast cells expressed 5-HT than the 5-HT1AR. Poorly differentiated tumours expressed fewer of both molecules, but the better differentiated mast cells at the periphery Of Such lesions had more consistent 5-HT expression. 5-HT and the 5-HT1A receptor may be involved in the differentiation of canine MCTs and in the microvascular complications associated with these neoplasms. (C) 2008 Elsevier Ltd. All rights reserved.