Incidence and distribution of parkinsonism in Olmsted County, Minnesota, 1976-1990
Incidence and distribution of parkinsonism in Olmsted County, Minnesota, 1976-1990
复制标题
DOI：
10.1212/wnl.52.6.1214
复制
发表时间：
1999-04-12
期刊：
影响因子：
9.9
通讯作者：
Rocca, WA
中科院分区：
文献类型：
--
作者：
Bower, JH;Maraganore, DM;Rocca, WA
目的：帕金森综合征作为一种综合征的频率和分布的信息有限。我们研究了1976年至1990年期间明尼苏达州奥姆斯特德县居民中帕金森症的发病率及其特殊类型。方法：我们使用罗切斯特流行病学项目的医疗记录链接系统来识别所有记录中包含任何形式的帕金森综合症、相关的神经退行性疾病或任何类型的震颤的个人。护士抽象员筛选记录，如果适用，神经科医生审查它们，以确定是否存在帕金森症，使用特定的诊断标准，并确定发病年份。结果：共发现帕金森综合征364例，其中帕金森病154例(42%)，帕金森病72例(20%)，不明原因帕金森病61例(17%)，痴呆帕金森综合征51例(14%)，乙醚原因26例(7%)。帕金森病的年平均发病率(每10万人年发病率)在50~99岁年龄组为114.7，发病率从0~29岁年龄组的0.8%急剧上升到80~99岁年龄组的304.8。假设没有相互竞争的死亡原因，帕金森氏症的累积发病率为7.5%至90岁。帕金森氏症是最常见的帕金森氏症，其次是男性痴呆症中的帕金森症和女性中药物诱导的帕金森症。除药物引起的帕金森症外，所有类型的帕金森症男性的发病率均高于女性。结论：帕金森氏症是老年人的常见病，其发病率随着年龄的增长而急剧增加，在男性中的发病率一直较高。按类型划分的分布因年龄和性别而异。
Objective: Limited information is available on the frequency and distribution of parkinsonism as a syndrome. We studied the incidence of parkinsonism and its specific types among residents of Olmsted County, MN, for the period from 1976 through 1990. Methods: We used the medical records linkage-system of the Rochester Epidemiology Project to identify all individuals whose records contained documentation of any form of parkinsonism, related neurodegenerative diseases, or tremor of any type. A nurse abstractor screened the records, and, when applicable, a neurologist reviewed them to determine the presence of parkinsonism using specified diagnostic criteria and to define the year of onset. Results: We found 364 incident cases of parknsonism: 154 with PD (42%) 72 with drug-induced parkinsonism (20%, 61 unspecified (17%), 51 with parkinsonism in dementia (14%), and 26 with ether causes (7%). The average annual incidence rate of parkinsonism (per 100,000 person-years) in the age group 50 to 99 years was 114.7; incidence increased steeply with age from 0.8 in the age group 0 to 29 years to 304.8 in the age group 80 to 99 years. The cumulative incidence of parkinsonism assuming no competing causes of death was 7.5% to age 90 years. PD was the most common type of parkinsonism, followed by parkinsonism in dementia in men and drug-induced parkinsonism in women. Men had higher incidence than women at all ages for all types of parkinsonism except drug-induced. Conclusions: Parkinsonism is a common disease among the elderly; its incidence increases steeply with advancing age and is consistently higher in men. The distribution by type changes with age and gender.