Sesquiterpene lactones from the pericarps of Illicium majus; 2-oxy derivatives of neomajucin and 3,4-dehydroxyneomajucin.
Sesquiterpene lactones from the pericarps of Illicium majus; 2-oxy derivatives of neomajucin and 3,4-dehydroxyneomajucin.
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DOI：
10.1248/cpb.38.422
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发表时间：
1990-02
影响因子：
1.7
通讯作者：
I. Kouno;N. Baba;M. Hashimoto;N. Kawano;Masakatsu Takahashi;H. Kaneto;Chun-Shu Yang
中科院分区：
文献类型：
--
作者：
I. Kouno;N. Baba;M. Hashimoto;N. Kawano;Masakatsu Takahashi;H. Kaneto;Chun-Shu Yang
从八角果皮中分离得到6个大茴香素类倍半萜内酯。这些化合物(4-9)的结构被鉴定为具有2-氧基的大黄素。值得注意的是，六种化合物中有一种具有(10S*)-羟基，而通常的茴香素和大黄素类化合物具有(10R*)-羟基。所有这些结构都是在光谱数据的基础上确定的，并与大黄素和新菊素的结构进行了比较。这些化合物没有表现出对小鼠的惊厥毒性，尽管没有检测到(10S*)-羟基化合物。
Six more anisatin-like sesquiterpene lactones were isolated from the pericarps of Illicium majus. The structures of these sompounds (4-9) were characterized as majucins having a 2-oxy group. It is noteworthy that one of the six compounds has a (10S*)-hydroxyl group, whereas usual anisatin- and majucin-type compounds have a (10R*)-hydroxyl group. All these structures were determined on the basis of spectral data, compard with those of majucin and neomajucin. These compounds did not exhibit convulsive toxicity to mice, although the (10S*)-hydroxy compound was not examined.