Aging and the Resting State: Is Cognition Obsolete?
Aging and the Resting State: Is Cognition Obsolete?
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DOI：
10.1080/23273798.2016.1227858
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Schacter DL
中科院分区：
文献类型：
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作者：
Campbell KL;Schacter DL
近年来，神经认知老化的静息状态方法越来越受欢迎，许多研究检查了静息时功能连接的年龄差异，并将这些差异与扫描仪外的认知表现联系起来。静息状态有许多优点，这可能有助于它的流行，事实上，从这项工作中获得了许多见解。然而，静息状态方法也有一些局限性，限制了其对神经认知老化研究的贡献。在这篇观点文章中，我们考虑了其中的一些局限性，并认为基于任务的研究对于发展年龄如何以认知相关的方式影响大脑的机械理解仍然至关重要-这是神经科学研究衰老的基本目标。
Recent years have seen the rise in popularity of the resting state approach to neurocognitive aging, with many studies examining age differences in functional connectivity at rest and relating these differences to cognitive performance outside the scanner. There are many advantages to the resting state that likely contribute to its popularity and indeed, many insights have been gained from this work. However, there are also several limitations of the resting state approach that restrict its ability to contribute to the study of neurocognitive aging. In this opinion piece, we consider some of those limitations and argue that task-based studies are still essential to developing a mechanistic understanding of how age affects the brain in a cognitively relevant manner – a fundamental goal of neuroscientific research into aging.