Serum microRNA expression in pregnancies with preeclampsia
Serum microRNA expression in pregnancies with preeclampsia
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DOI：
10.4238/2011.november.8.5
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发表时间：
2011-01-01
影响因子：
0.4
通讯作者：
Aydinli, K.
中科院分区：
文献类型：
--
作者：
Gunel, T.;Zeybek, Y. G.;Aydinli, K.
先兆子痫仍然是全世界孕妇的致命疾病。最近，遗传学家与产科医生联手，开辟了新的领域。MicroRNA（miRNAs）是一类小的非编码RNA分子的成员。它们是基因表达的关键转录后调节因子。我们从母体血浆中提取循环miRNA，并定量mir 152和mir-210。我们发现在先兆子痫患者中miR-210水平上调以及miR-152水平下调。我们建议检测孕妇血清中mir-210水平的增加可以用于改进先兆子痫的无创产前诊断的预测方法。
Preeclampsia continues to be a mortal disease of pregnant women throughout the world. Recently, geneticists, allied with obstetricians, have opened new frontiers. MicroRNAs (miRNAs) are members of a class of small, noncoding RNA molecules. They are critical posttranscriptional regulators of gene expression. We extracted circulating miRNA from maternal plasma and quantified mir152 and mir-210. We found up-regulated miR-210 levels as well as down-regulated mir-152 levels in preeclampsia patients. We propose that detection of increased mir-210 levels in maternal serum could be used to improve prediction methods for noninvasive prenatal diagnosis of preeclampsia.