THERMAL STIMULATION OF ELECTRICAL ACTIVITY OF SINGLE UNITS OF PREOPTIC REGION
THERMAL STIMULATION OF ELECTRICAL ACTIVITY OF SINGLE UNITS OF PREOPTIC REGION
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DOI：
10.1152/ajplegacy.1963.204.6.1122
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发表时间：
1963-01-01
影响因子：
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通讯作者：
EISENMAN, JS
中科院分区：
文献类型：
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作者：
NAKAYAMA, T;HAMMEL, HT;EISENMAN, JS
用乌拉坦麻醉的猫，在局部加热和冷却下丘脑时，记录到下丘脑和视前区的单个单位活动。通过射频电流（3.7兆周/秒）进行加热，并通过使温水和冷水循环通过置于中线两侧4-6 mm处的小钢热电偶进行加热和冷却。通过热电偶和热敏电阻记录局部组织温度。从一项对大约1,000个神经元的研究中观察到：a）大约五分之一的神经元随着局部温度从32 ℃升高到41 ℃而增加其自发放电速率B）在34-41 ℃温度范围内，80%的细胞对温度变化无反应，自发放电率无变化; c）仅在前连合吻腹侧的中线区域发现热敏神经元; d）未发现放电频率随局部温度降低而增加的单位。
Single unit activity has been recorded in the hypothalamus and preoptic region of cats anesthetized with urethan during local hypothalamic heating and cooling. Heating was accomplished by radio frequency current (3.7 megacycles/sec) and heating and cooling by circulating warm and cold water through small steel thermodes placed 4-6 mm on each side of the midline. Local tissue temperature was recorded by thermocouples and by thermistors. It was observed from a study of about 1,000 neurons that a) about one neuron in five increased its rate of spontaneous discharge with increase in local temperature from 32 to 41 C (Q10 = 5-15); b) 80% of the units did not respond to temperature change by changing their spontaneous discharge rate in the 34-41 C temperature range; c) thermally sensitive neurons were found only in the midline region immediately rostroventral to the anterior commissure; d) no units were found for which the discharge frequency increased by decreasing the local temperature.