A longitudinal study of plasma and salivary antibodies in HIV-1 infection.
A longitudinal study of plasma and salivary antibodies in HIV-1 infection.
复制标题
HIV-1 感染中血浆和唾液抗体的纵向研究。
DOI：
10.1089/08828240260066251
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Jackson,Susan
中科院分区：
文献类型：
--
作者：
Wu,Xueling;Jackson,Susan
血浆和唾液中的IgG和伊加抗体反应的HIV-1蛋白质的模式，在7个HIV-1感染者的一段时间为18-40个月。蛋白质印迹分析显示 受试者中这些抗体的特异性有所不同;然而，对于同一受试者，特异性特征在整个随访期间保持一致。染色强度 两名受试者的血浆IgG水平与血浆病毒载量相关。唾液IgG的条带强度主要由血浆IgG决定，口腔健康状况也可能影响唾液IgG的条带强度。 唾液IgG抗体漏出。某些病毒蛋白特异性的血浆和唾液伊加抗体的结合强度也与某些受试者的血浆病毒载量相关。
The patterns of plasma and salivary IgG and IgA antibodies reacting to HIV-1 proteins were followed in seven HIV-1–infected individuals for a period of 18–40 months. Western blot analyses revealed diversities in specificity of these antibodies among subjects; however, for the same subject, the specificity profile remained consistent throughout the entire follow-up period. The staining intensities of plasma IgG from two subjects were associated with plasma viral load. The band intensities of salivary IgG were mostly determined by plasma IgG; the health of the oral cavity might also influence the transudation of salivary IgG antibodies. The binding intensities of plasma and salivary IgA antibodies specific for certain viral proteins were associated with plasma viral load in some subjects as well.