Spinal nerve ligation-induced activation of nuclear factor kappaB is facilitated by prostaglandins in the affected spinal cord and is a critical step in the development of mechanical allodynia
Spinal nerve ligation-induced activation of nuclear factor kappaB is facilitated by prostaglandins in the affected spinal cord and is a critical step in the development of mechanical allodynia
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DOI：
10.1016/j.neuroscience.2008.04.077
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发表时间：
2008-08-26
期刊：
影响因子：
3.3
通讯作者：
Loomis, C. W.
中科院分区：
文献类型：
--
作者：
O'Rielly, D. D.;Loomis, C. W.
本研究探讨了第5和第6腰神经（1-5/1-6）脊神经结扎（SNL）对大鼠腰段背角核提取物中活化的核因子κ B（NFkBa）的影响及其与前列腺素（PG）依赖性脊髓过度兴奋和异常性疼痛的关系。雄性Sprague-Dawley大鼠，鞘内（i.t.）导管，接受SNL或假手术。采用缩爪阈值（PWT）、股二头肌屈肌反射的肌电图分析和脊髓免疫印迹。两种异常性疼痛（PWT
This study investigated the effect of 5th and 6th lumbar nerve (1-5/1-6) spinal nerve ligation (SNL) on activated nuclear factor kappaB (NFkBa) in nuclear extracts from the lumbar dorsal horn of the rat, and its relationship to prostaglandin (PG)-dependent spinal hyperexcitability and allodynia 3 days later. Male Sprague-Dawley rats, fitted with intrathecal (i.t.) catheters, underwent SNL- or sham-surgery. Paw withdrawal threshold (PWT), electromyographic analysis of the biceps femoris flexor reflex, and immunoblotting of the spinal cord were used. Both allodynia (PWT