Emerging concept of anti-hypertensive therapy based on ambulatory blood pressure profile in chronic kidney disease.
Emerging concept of anti-hypertensive therapy based on ambulatory blood pressure profile in chronic kidney disease.
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发表时间：
2011
影响因子：
1.3
通讯作者：
K. Tamura;T. Kanaoka;Masato Ohsawa;Sona Haku;K. Azushima;Akinobu Maeda;Toru Dejima;H. Wakui;M. Ozawa;Atsu-ichiro Shigenaga;Y. Toya;S. Umemura
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作者：
K. Tamura;T. Kanaoka;Masato Ohsawa;Sona Haku;K. Azushima;Akinobu Maeda;Toru Dejima;H. Wakui;M. Ozawa;Atsu-ichiro Shigenaga;Y. Toya;S. Umemura
目前高血压合并慢性肾脏疾病（CKD）特别是糖尿病肾病的患者越来越多，心血管和肾脏并发症是这些患者最常见的死亡原因。控制血压是CKD合并高血压患者心血管和肾脏保护的一个重要问题。虽然高血压的诊断通常基于就诊时记录的血压，即办公室血压，但一些研究表明，靶器官损伤和预后与动态血压的关系比与办公室血压的关系更密切。对于高血压患者来说，通过办公室或家庭测量或通过门诊记录来达到目标绝对血压水平对于心血管和肾脏保护是很重要的。测量动态血压的无创技术已经允许在白天和夜间监测血压。此外，动态血压监测可以提供昼夜血压变化和短期血压变异性的信息，这被认为与心血管和肾脏的发病率和死亡率有关。本文将简要总结基于CKD高血压患者动态血压谱的降压治疗的新概念。
Presently hypertensive patients with chronic kidney disease (CKD) particularly diabetic nephropathy are increasing in number, and cardiovascular and renal complications are the most common cause of death in these patients. The control of blood pressure (BP) is an important issue in cardiovascular and renal protection in hypertensive patients with CKD. Although hypertension is usually diagnosed based on measurements of BP recorded during a visit to a physician, that is, office BP, several studies have shown that target organ damage and prognosis are more closely associated with ambulatory BP than with office BP. It should be important to achieve the target absolute BP levels in hypertensive patients obtained either by office or home measurements or by ambulatory recordings for the cardiovascular and renal protection. Noninvasive techniques for measuring ambulatory BP have allowed BP to be monitored during both day and night. Additionally, ambulatory BP monitoring can provide information on circadian BP variation and short-term BP variability, which is suggested to be associated with cardiovascular and renal morbidity and mortality. This review will briefly summarize the emerging concept of anti-hypertensive therapy based on ambulatory BP profile in hypertensive patients with CKD.