Pre- and post-diagnosis body mass index, weight change, and ovarian cancer mortality.
Pre- and post-diagnosis body mass index, weight change, and ovarian cancer mortality.
复制标题
诊断前和诊断后的体重指数、体重变化和卵巢癌死亡率。
DOI：
10.1016/j.ygyno.2010.10.035
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发表时间：
2011
影响因子：
4.7
通讯作者：
Risch,HarveyA
中科院分区：
文献类型：
--
作者：
Zhou,Yang;Irwin,MelindaL;Risch,HarveyA
OBJECTIVEThe purpose of this study was (1) to investigate the association between BMI self-reported at three time points (during their 20s, 5years before diagnosis, and post-diagnosis) and mortality among 388 women with newly diagnosed epithelial ovarian cancer and (2) weight change between these 3 time points and mortality.METHODSWomen completed interview-administered questionnaires on average 9months post-diagnosis. Women were followed 5years after diagnosis or until death, whichever came first. Cox proportional hazard regression was used to estimate associations between BMI during the 20s, BMI 5years prior to diagnosis, BMI post-diagnosis (i.e., at the time of interview) and weight changes between these time points and mortality.RESULTSThe 5-year survival rate was 54% (178 deaths, 146 from ovarian cancer). BMI measured continuously at all three time points was associated with a higher risk of ovarian cancer mortality (P≤0.05). The strongest association was observed with BMI in the 20s and all-cause mortality comparing women with BMI≥25kg/m2to BMI<25kg/m2(HR=1.82; 95% CI, 1.02–3.27; P for trend=0.045). For weight change from the 20s to 5years prior to diagnosis and ovarian cancer specific mortality, we observed a 68% higher risk of ovarian cancer mortality (HR=1.68; 95% CI, 1.11–2.55; P for trend=0.015, comparing women with <10 lbs weight gain to women with ≥10 lbs weight gain).CONCLUSIONBMI prior to and after diagnosis and weight gain throughout adulthood is associated with ovarian cancer mortality.
