MR image-based synthetic CT for IMRT prostate treatment planning and CBCT image-guided localization.
MR image-based synthetic CT for IMRT prostate treatment planning and CBCT image-guided localization.
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DOI：
10.1120/jacmp.v17i3.6065
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发表时间：
2016-05-08
影响因子：
2.1
通讯作者：
Yan D
中科院分区：
文献类型：
--
作者：
Chen S;Quan H;Qin A;Yee S;Yan D
本研究的目的是提出并评价一种通过MRI模拟创建合成CT（S-CT）的方法，用于剂量计算和每日CBCT定位。在同一天从10名前列腺患者中获得一对MR和CT图像。使用可变形图像配准（DERM）对MR和CT图像进行预配准。使用相应的位移矢量场（atlas-DVF），将CT图像变形为MR图像，以创建图谱MR-CT对。在图谱MR-CT对上描绘感兴趣区域（ROI），并用于创建图谱-ROI掩模。进行了“留一法”检验（将一对MR和CT用作受试者-MR和受试者-CT进行评价，其余9对在图谱库中）。对于受试者-MR，使用受试者-MR和9个atlas-MR之间的插值生成自动分割和DVF。然后使用相应的9对atlas-CT、9个atlas-DVF和相应的atlas-ROI掩模生成S-CT。使用Hounsfield单位（HU）、计算的剂量分布和与10个受试者CT的每日CBCT图像的自动骨配准对总共10个S-CT进行评价。前列腺、膀胱、直肠壁、所有ROI外的软组织和骨的HU差异分别为、和。使用S-CT计算的治疗计划剂量体积参数的差异较小（95%置信度）。在PTV和正常结构中，γ射线通过率（2% & 2 mm）分别为99.86%和98.45%。使用10个S-CT作为每日CBCT定位的参考CT，与使用申报CT相比，获得了相似的结果。在所有三个方向上，平移向量差在1.08 mm内，旋转差在1.1°内。使用所提出的方法和预构建的图谱库从模拟MR图像创建的S-CT可以替代计划CT进行剂量计算和每日CBCT图像引导。PACS编号：87.57.nf，87.57.nm
The purpose of this study was to propose and evaluate a method of creating a synthetic CT (S‐CT) from MRI simulation for dose calculation and daily CBCT localization. A pair of MR and CT images was obtained in the same day from each of 10 prostate patients. The pair of MR and CT images was preregistered using the deformable image registration (DIR). Using the corresponding displacement vector field (atlas‐DVF), the CT image was deformed to the MR image to create an atlas MR‐CT pair. Regions of interest (ROI) on the atlas MR‐CT pair were delineated and used to create atlas‐ROI masks. ‘Leave‐one‐out’ test (one pair of MR and CT was used as subject‐MR and subject‐CT for evaluation, and the remaining 9 pairs were in the atlas library) was performed. For a subject‐MR, autosegmentation and DVFs were generated using DIR between the subject‐MR and the 9 atlas‐MRs. An S‐CT was then generated using the corresponding 9 paired atlas‐CTs, the 9 atlas‐DVFs and the corresponding atlas‐ROI masks. The total 10 S‐CTs were evaluated using the Hounsfield unit (HU), the calculated dose distribution, and the auto bony registration to daily CBCT images with respect to the 10 subject‐CTs. HU differences were , , , , and for prostate, bladder, rectal wall, soft tissue outside all ROIs, and bone, respectively. The discrepancy of dose‐volume parameters calculated using the S‐CT for treatment planning was small ( with 95% confidence). Gamma pass rate (2% & 2 mm) was higher than 99.86% inside PTV and 98.45% inside normal structures. Using the 10 S‐CTs as the reference CT for daily CBCT localization achieved the similar results compared to using the subject‐CT. The translational vector differences were within 1.08 mm , and the rotational differences were within 1.1° in all three directions. S‐CT created from a simulation MR image using the proposed approach with the preconstructed atlas library can replace the planning CT for dose calculation and daily CBCT image guidance. PACS number(s): 87.57.nf, 87.57.nm
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影响因子：
3.1
作者：
Korhonen, Juha;Kapanen, Mika;Tenhunen, Mikko
通讯作者：
Tenhunen, Mikko
影响因子：
3.5
作者：
Hsu SH;Cao Y;Lawrence TS;Tsien C;Feng M;Grodzki DM;Balter JM
通讯作者：
Balter JM
影响因子：
3.5
作者：
Sjolund, J.;Forsberg, D.;Knutsson, H.
通讯作者：
Knutsson, H.
DOI：
10.1016/j.ijrobp.2004.05.068
发表时间：
2004-10-01
影响因子：
7
作者：
Chen, LL;Price, RA;Pollack, A
通讯作者：
Pollack, A
影响因子：
3.5
作者：
Gudur MS;Hara W;Le QT;Wang L;Xing L;Li R
通讯作者：
Li R