Neurotoxicity of continuous (90 days) inhalation of technical grade methyl butyl ketone in hens.
Neurotoxicity of continuous (90 days) inhalation of technical grade methyl butyl ketone in hens.
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母鸡连续（90 天）吸入工业级甲基丁基酮的神经毒性。
DOI：
10.1080/15287398209530155
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
M. B. Abou
中科院分区：
文献类型：
--
作者：
K. Abdo;D. Graham;P. Timmons;M. B. Abou
通过在吸入室中连续90天暴露于含有50、100、200或400 ppm工业级甲基丁基酮（MBK）（含70%甲基正丁基酮（MnBK）和30%甲基异丁基酮（MiBK））的大气中，在1岁母鸡（每次处理5只母鸡）中产生神经毒性。观察期为30 d。临床状况的严重程度和神经功能缺损体征的进展或改善取决于MBK的浓度和暴露时间。暴露于两种最高水平的母鸡出现共济失调和瘫痪;它们在指定的暴露期结束前死亡或被处死。中等水平的MBK（100 ppm）引起严重共济失调;大多数给药母鸡在观察期间的临床状况没有变化。暴露于50 ppm的母鸡表现出严重的共济失调，大多数表现出神经功能缺损在暴露停止后部分消退。暴露于最低测试水平（10 ppm）的母鸡保持正常。只有接触400或200 ppm的母鸡体重明显减轻。50-400 ppm处理组的一些母鸡在脊髓和外周神经中显示出明确的组织病理学变化。组织病理学变化的严重程度取决于MBK暴露的水平和持续时间。这些变化的特点是过度肿胀，吞噬作用，变性和脱髓鞘的轴突。
Neurotoxicity was produced in 1-yr-old hens (five hens per treatment) by continual 90-d exposure in inhalation chambers to atmospheres containing 50, 100, 200, or 400 ppm technical grade methyl butyl ketone (MBK) containing 70% methyl n-butyl ketone (MnBK) and 30% methyl isobutyl ketone (MiBK). A 30-d observation period followed. Severity of clinical condition and progression or improvement of neurological deficit signs were dependent on the concentration of MBK and duration of exposure. Hens exposed to the two highest levels developed ataxia and paralysis; they died or were sacrificed before the designated exposure period ended. The intermediate level of MBK (100 ppm) caused severe ataxia; most treated hens showed no change in clinical condition during the observation period. Hens exposed to 50 ppm exhibited gross ataxia, with most demonstrating partial regression of neurological deficit after the exposure ceased. Hens exposed to the lowest tested level (10 ppm) remained normal. Only hens exposed to 400 or 200 ppm showed significant weight loss. Some hens from the 50-400 ppm treatment groups showed unequivocal histopathologic changes in the spinal cord and peripheral nerves. Severity of histopathologic changes depended on the level and duration of MBK exposure. These changes were characterized by excessive swelling, phagocytosis, degeneration, and demyelination of the axons.
影响因子：
5.9
作者：
Peter S. Spencer;Herbert H. Schaumburg;Mohammad I. Sabri;Bellina Veronesi;G. Divincenzo
通讯作者：
Peter S. Spencer;Herbert H. Schaumburg;Mohammad I. Sabri;Bellina Veronesi;G. Divincenzo