Antiallergic activity of aqueous extracts and constituents of Taxus yunnanensis
Antiallergic activity of aqueous extracts and constituents of Taxus yunnanensis
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DOI：
10.1248/bpb.29.2310
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发表时间：
2006-11-01
影响因子：
2
通讯作者：
Kadota, Shigetoshi
中科院分区：
文献类型：
--
作者：
Koyama, Junko;Morita, Izumi;Kadota, Shigetoshi
云南红豆杉木材的H2O、HZO/MeOH(1：1)提取物对人嗜碱细胞系KU812的组胺释放有明显的抑制作用。采用体外组胺释放抑制法对云南红豆杉木材提取物中的11种化学成分进行了测定。其中，二异阿糖醇和紫杉醇表现出抑制活性。从云南红豆杉木材中分离得到新木脂素2-[2-hydroxy5-(3-hydroxypropyl)-3-methoxyphenyl]-1-(4-hydroxy-3-methoxyphenyl)propane-1，3-diol，。
The H2O, HZO/MeOH (1: 1) extracts from the wood of Taxus yunnanensis showed a remarkable inhibitory effect on induced histamine release from the human basophilic cell line, KU812. The eleven constituents purified from the wood extracts of Taxus yunnanensis were tested by an in vitro histamine release inhibition assay. Among them, secoisolarciresinol and taxiresinol were found to show inhibitory activities. A new neolignan, 2-[2-hydroxy5-(3-hydroxypropyl)-3-methoxyphenyl]-1-(4-hydroxy-3-methoxyphenyl)propane-1,3-diol, was isolated from the wood of Taxus yunnanensis.