Phase-Variable Expression of lptA Modulates the Resistance of Neisseria gonorrhoeae to Cationic Antimicrobial Peptides
Phase-Variable Expression of lptA Modulates the Resistance of Neisseria gonorrhoeae to Cationic Antimicrobial Peptides
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DOI：
10.1128/aac.03108-14
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发表时间：
2014-07-01
影响因子：
4.9
通讯作者：
Shafer, William M.
中科院分区：
文献类型：
--
作者：
Kandler, Justin L.;Joseph, Sandeep J.;Shafer, William M.
淋球菌产生的类脂A的磷乙醇胺(PEA)修饰与细菌对阳离子抗菌肽/蛋白(CAMP)的耐药性和实验感染期间体内的适合性有关。我们现在报告，编码负责这种修饰的PEA转移酶的LPTA基因存在于操纵子中，LPTA内多核苷酸重复的高频突变可以影响淋球菌对cAMP的耐药性。
Phosphoethanolamine (PEA) decoration of lipid A produced by Neisseria gonorrhoeae has been linked to bacterial resistance to cationic antimicrobial peptides/proteins (CAMPs) and in vivo fitness during experimental infection. We now report that the lptA gene, which encodes the PEA transferase responsible for this decoration, is in an operon and that high-frequency mutation in a polynucleotide repeat within lptA can influence gonococcal resistance to CAMPs.