Chlorpromazine plasma levels and effects.
Chlorpromazine plasma levels and effects.
复制标题
氯丙嗪血浆水平和影响。
DOI：
10.1001/archpsyc.1970.01740280001001
复制
发表时间：
1970
影响因子：
--
通讯作者：
D. Janowsky
中科院分区：
文献类型：
--
作者：
S. Curry;J. H. Marshall;J. Davis;D. Janowsky
对氯丙嗪的代谢和组织分布进行了广泛的研究，1，2然而，试图将临床效应与药物命运和处置的变化联系起来的尝试一直是徒劳的。3-7在大多数此类研究中，通过非特异性方法测定尿液中的药物及其代谢产物。然而，越来越明显的是，对于许多药物，反应与药物（或活性代谢物）的血浆水平的关系比与药物及其非活性代谢物的尿排泄率的关系更密切。8，9对药物反应的个体差异可能是由吸收和代谢速率的变化引起的血浆水平的变化引起的。血浆水平的变化在高脂溶性药物的情况下特别明显，例如用于精神药理学的药物。10如果这些变化可以通过剂量方案10、11控制，
THE metabolism and tissue distribution of chlorpromazine have been studied extensively, 1,2 yet attempts to correlate clinical effects with variations in the fate and disposition of the drug have been unrewarding. 3-7 In most studies of this type the drug and its metabolites have been assayed in urine by nonspecific methods. It is becoming increasingly apparent, however, that for many drugs responses are related more closely to plasma levels of the drug (or active metabolites) than to urinary excretion rates of the drugs and their inactive metabolites. 8,9 Individual variation in response to drugs may be caused by variations in plasma levels, resulting from variations in rates of absorption and metabolism. Variations in plasmalevels are particularly marked in the case of highly lipid-soluble drugs, such as those used in psychopharmacology. 10 If these variations could be controlled by dosage regimens 10,11 that would