Role of p53 family in birth defects: Lessons from zebrafish
Role of p53 family in birth defects: Lessons from zebrafish
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DOI：
10.1002/bdrc.20129
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发表时间：
2008-09-01
影响因子：
2.1
通讯作者：
Lin, Shuo
中科院分区：
文献类型：
--
作者：
Danilova, Nadia;Sakamoto, Kathleen M.;Lin, Shuo
p53蛋白家族是一个重要的致畸抑制因子，但在某些情况下可导致先天性畸形。p53家族在发育过程中扮演着双重角色，它整合来自细胞内部和环境的信息，决定生与死的选择。了解p53家族的发育功能可能会导致新的治疗方法，治疗和预防出生缺陷。斑马鱼正在成为研究p53家族在发育中作用的脊椎动物系统的选择。
p53 protein family is an important teratologic suppressor, but in certain conditions it can cause congenital abnormalities. p53 family performs this dual role in development by integrating information from cell's interior with that from the environment to determine the choice between life and death. Understanding of p53 family developmental functions may lead to new therapeutic approaches for treatment and prevention of birth defects. Zebrafish is becoming the vertebrate system of choice for studying p53 family role in development.