Effects of psychotropic drugs on methamphetamine-induced behavioral excitation in grouped mice.
Effects of psychotropic drugs on methamphetamine-induced behavioral excitation in grouped mice.
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DOI：
10.1016/0014-2999(75)90040-0
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发表时间：
1975-04
影响因子：
5
通讯作者：
K. Shintomi
中科院分区：
文献类型：
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作者：
K. Shintomi
当7只小鼠注射甲基苯丙胺（5 mg/kg，s.c.）被一起放入一个空间有限、温度保持在28-30°C的盒子中，分组小鼠表现出极端的行为兴奋，包括2个典型特征：带有吱吱声的打斗行为和以奔跑和跳跃为特征的多动行为。根据最小有效剂量（mg/kg，p.o.）分别抑制战斗行为和多动行为的药物为：氟哌啶醇，0.1（战斗）- 0.25（多动）;噻氯噻嗪，1 - 1;奋乃静，1 - 1;噻吨，1 - 5;氯丙嗪，5 - 10;地西泮，5 - 100 μ l;利血平，100 μ l- 100 μ l;酚苄明，200 μ l- 200 μ l（无作用）。除了萝芙木生物碱的主要镇静剂完全抑制这两种类型的兴奋行为在低剂量下，相比之下，在对小鼠的脚震诱导的战斗事件的药物的驯服效果。另一方面，轻微的镇静剂只抑制了打斗行为，对多动行为几乎没有影响。抗抑郁药、肾上腺素能阻滞剂和其他药物都没有对这两种兴奋行为表现出拮抗作用。结果表明，该方法可用于精神药物分组效应的评价。
When 7 mice injected with methamphetamine (5 mg/kg, s.c.) were placed together into a box with a limited space maintained at 28–30°C, the grouped mice showed extreme behavioral excitation consisting of 2 typical features: fighting behavior with squeak and hyperactive behavior characterized by running and jumping. The effects of various drugs tested, according to the minimal effective doses (mg/kg, p.o.) which inhibited fighting behavior and hyperactive behavior respectively, were: haloperidol, 0.1 (fighting) - 0.25 (hyperactivity); clothiapine, 1 - 1; perphenazine, 1 - 1; thiothixene, 1 - 5; chlorpromazine, 5 - 10; diazepam, 5 - 100∗; reserpine, 100∗- 100∗; phenoxybenzamine, 200∗- 200∗(∗no effect). Major tranquilizers except rauwolfia alkaloids completely inhibited both types of excited behavior at low doses, as compared with the taming effects of the drugs on footshock-induced fighting episodes in pairs of mice. On the other hand, minor tranquilizers suppressed only fighting behavior, showing little effect on hyperactive behavior. None of the antidepressants, adrenergic blocking agents and other drugs showed antagonism to both types of excited behavior. The results indicate that this method may be useful for the evaluation of psychotropic drug effects in grouped mice.