Temporal flexibility of gene regulatory network underlies a novel wing pattern in flies
Temporal flexibility of gene regulatory network underlies a novel wing pattern in flies
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DOI：
10.1073/pnas.2002092117
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发表时间：
2020-05-26
影响因子：
11.1
通讯作者：
Finet, Cedric
中科院分区：
文献类型：
--
作者：
Dufour, Heloise D.;Koshikawa, Shigeyuki;Finet, Cedric
生物在进化过程中进化出了无数形态、生理和行为上的新特征。新性状的进化主要是通过预先存在的基因的协调作用。在过去的二十年里，生物学家已经证明，基因调控网络（grn）的选择确实是许多进化新现象的基础。然而，我们对允许这种重新部署的实际GRN属性知之甚少。在这里，我们研究了果蝇Samoaia leonensis复杂翅膀图案的产生和进化。我们表明，转录因子Engrailed是独立于其他参与者的前-后规范网络，以产生一个新的翅膀模式。我们认为，部分合作是可能的，因为1)前后特异性GRN在发育翼中随时间的推移是灵活的，2)这种灵活性源于GRN的每个基因都有自己的功能时间窗口。我们提出GRN的时间灵活性是其在进化过程中可能选择的一般先决条件。
Organisms have evolved endless morphological, physiological, and behavioral novel traits during the course of evolution. Novel traits were proposed to evolve mainly by orchestration of preexisting genes. Over the past two decades, biologists have shown that cooption of gene regulatory networks (GRNs) indeed underlies numerous evolutionary novelties. However, very little is known about the actual GRN properties that allow such redeployment. Here we have investigated the generation and evolution of the complex wing pattern of the fly Samoaia leonensis. We show that the transcription factor Engrailed is recruited independently from the other players of the anterior-posterior specification network to generate a new wing pattern. We argue that partial cooption is made possible because 1) the anterior-posterior specification GRN is flexible over time in the developing wing and 2) this flexibility results from the fact that every single gene of the GRN possesses its own functional time window. We propose that the temporal flexibility of a GRN is a general prerequisite for its possible cooption during the course of evolution.