The foundations of cross-modal plasticity.
The foundations of cross-modal plasticity.
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DOI：
10.1080/19420889.2016.1158378
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发表时间：
2016-03-01
影响因子：
--
通讯作者：
Bai, Jihong
中科院分区：
文献类型：
--
作者：
Rabinowitch, Ithai;Bai, Jihong
跨模态可塑性是大脑的一个显著的自适应特征，其中一种感觉模态的丧失会诱导皮层重组，从而增强其余模态的感觉性能。关于大脑中的宏观变化，我们已经知道很多，这些变化是跨模态可塑性和感官表现相关变化的基础。相反，关于这种机制的分子和细胞基础的信息相对较少。我们假设跨模态可塑性是神经系统的一个基本特征。因此，它应该存在于大脑远不如我们复杂的生物体中。事实上，我们发现了一个跨模式的可塑性机制，在蛔虫秀丽隐杆线虫，其神经系统是由只有302个神经元。利用C. elegans神经系统，我们能够全面研究跨模态可塑性，从分子到电路到行为。
Cross-modal plasticity is a striking adaptive feature of the brain, whereby the loss of one sensory modality induces cortical reorganization that leads to enhanced sensory performance in remaining modalities. Much is known about the macroscopic modifications in the brain that underly cross-modal plasticity and the associated changes in sensory performance. In contrast there is relatively scant information about the molecular and cellular underpinnings of this mechanism. We hypothesized that cross-modal plasticity is a fundamental feature of the nervous system. As such, it should be found in organisms with brains that are substantially less complex than our own. Indeed, we discovered a cross-modal plasticity mechanism in the roundworm Caenorhabditis elegans, whose nervous system is composed of only 302 neurons. Taking advantage of the simplicity of the C. elegans nervous system, we were able to comprehensively study cross-modal plasticity from molecule through circuit to behavior.