Effect of thymosin on T-lymphocyte functions in patients with acute thermal burns.
Effect of thymosin on T-lymphocyte functions in patients with acute thermal burns.
复制标题
胸腺肽对急性热烧伤患者T淋巴细胞功能的影响。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
J. C. Daniels
中科院分区：
文献类型：
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作者：
S. Ishizawa;H. Sakai;H. Sarles;D. Larson;J. C. Daniels
严重热烧伤的患者表现出细胞免疫功能下降。本研究的目的是确定胸腺肽是否能在体外增强此类患者的T淋巴细胞功能。连续采集22例烧伤患者和35例健康成人的外周血淋巴细胞。通过E-玫瑰花环形成、淋巴细胞对PHA、ConA、PWM、PPD、SK-SD、腮腺炎抗原和破伤风类毒素的反应以及混合淋巴细胞培养反应来评价淋巴细胞功能。这些测试是在体外添加和不添加胸腺肽的情况下进行的。大多数检测参数在烧伤后2周内显著降低。体外添加胸腺肽可显著恢复受损的淋巴细胞反应，混合淋巴细胞培养反应除外。这些结果表明，胸腺肽在体外能增强烧伤患者的某些T淋巴细胞功能。他们进一步表明，胸腺肽的应用可能会恢复严重烧伤患者细胞免疫功能的下降。
Patients with severe thermal burns demonstrate a decreased cellular immunity. The purpose of this study was to ascertain whether thymosin enhances in vitro T-lymphocyte functions in such patients. Peripheral blood lymphocytes were obtained serially from 22 burned patients and 35 health adults. In vitro lymphocyte functions were evaluated by E-rosette formation, lymphocyte culture responses to PHA, Con A, PWM, PPD, SK-SD, mumps antigen, and tetanus toxoid, and mixed lymphocyte culture reactions. These tests were performed with and without in vitro addition of thymosin. Most of the parameters examined were significantly decreased in patients during the first 2 weeks postburn. The in vitro addition of thymosin significantly restored impaired lymphocyte responses, except in mixed lymphocyte culture reactions. These results demonstrate that thymosin enhances certain in vitro T-lymphocyte functions in burned patients. They further suggest that the administration of thymosin may restore decreased cell-mediated immunity in severely burned patients.