Interethnic differences in omeprazole metabolism in the two S-mephenytoin hydroxylation phenotypes studied in Caucasians and Orientals.
Interethnic differences in omeprazole metabolism in the two S-mephenytoin hydroxylation phenotypes studied in Caucasians and Orientals.
复制标题
在白种人和东方人中研究的两种 S-美芬妥因羟基化表型中奥美拉唑代谢的种族间差异。
作者：
T. Ishizaki;Sohn Dr;K. Kobayashi;K. Chiba;L. Kh;Shin Sg;T. Andersson;C. Regårdh;Lou Yc;Y. Zhang
两项独立的研究表明，奥美拉唑在广泛代谢物(EM)中的5-羟化反应比在S-美苯妥因的不良代谢物(PM)中更快，而不是亚磺化。在高加索人、中国人和韩国人中，平均口腔清除量相似，没有显著差异(分别为85、73和59mlh-1 kg-1)。然而，高加索人EMS的几何平均清除量(950mlh-1 kg-1)高于中国EMS(426mlh-1 kg-1，p<；0.05)和韩国EMS(446mlh-1 kg-1，p<；0.01)。中国人(14.6%)和韩国人(12.6%)的PMS发生率高于瑞典高加索人(3.3%)。因此，东方人的EMS杂合子与纯合子的比例高于高加索人。这可能解释了奥美拉唑在白种人EMS中的清除率高于中国人和韩国人S-美芬妥因EMS中的清除率。
Two independent studies showed that the 5-hydroxylation, but not the sulfoxidation, of omeprazole is more rapid in extensive metabolizers (EMs) than in poor metabolizers (PMs) of S-mephenytoin. In Caucasian, Chinese, and Korean PMs, the mean oral clearances were similar and not significantly different (85, 73, and 59 ml h-1 kg-1, respectively). However, the geometric mean clearance in Caucasian EMs (950 ml h-1 kg-1) was higher than in both Chinese EMs (426 ml h-1 kg-1, p < 0.05) and Korean EMs (446 ml h-1 kg-1, p < 0.01). The incidence of PMs of S-mephenytoin is higher in Chinese (14.6%) and Koreans (12.6%) than in Swedish Caucasians (3.3%). Therefore, the proportion of heterozygous compared to homozygous EMs is higher in Orientals than in Caucasians. This might explain the higher clearance of omeprazole in Caucasian EMs compared to the clearance of omeprazole in Chinese and Korean EMs of S-mephenytoin.