Neuropilin-2 regulates the development of select cranial and sensory nerves and hippocampal mossy fiber projections
Neuropilin-2 regulates the development of select cranial and sensory nerves and hippocampal mossy fiber projections
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DOI：
10.1016/s0896-6273(00)80870-3
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发表时间：
2000-01-01
期刊：
影响因子：
16.2
通讯作者：
Tessier-Lavigne, M
中科院分区：
文献类型：
--
作者：
Chen, H;Bagri, A;Tessier-Lavigne, M
Neuropilin-1和neuropilin-2结合不同的3类semaphorins和被认为是提供受体复合物介导的排斥反应，这些semaphorins的配体结合部分。在这里，我们已经研究了神经纤毛蛋白-2的功能，通过分析神经纤毛蛋白-2突变小鼠，这是可行的和肥沃的。在突变体中，交感神经元和海马神经元对Sema 3F而不是对Sema 3A的排斥反应被废除。在几个脑神经的发育、脊髓感觉轴突的初始中枢投射、前连合、缰脚间束和海马苔藓纤维轴突在锥体束下的投射中观察到明显的缺陷。我们的研究结果表明，neuropilin-2是Sema 3F受体的重要组成部分，并确定neuropilin-2在PNS和CNS的轴突导向中的关键作用。
Neuropilin-1 and neuropilin-2 bind differentially to different class 3 semaphorins and are thought to provide the ligand-binding moieties in receptor complexes mediating repulsive responses to these semaphorins. Here, we have studied the function of neuropilin-2 through analysis of a neuropilin-2 mutant mouse, which is viable and fertile. Repulsive responses of sympathetic and hippocampal neurons to Sema3F but not to Sema3A are abolished in the mutant. Marked defects are observed in the development of several cranial nerves, in the initial central projections of spinal sensory axons, and in the anterior commissure, habenulo-interpeduncular tract, and the projections of hippocampal mossy fiber axons in the infrapyramidal bundle. Our results show that neuropilin-2 is an essential component of the Sema3F receptor and identify key roles for neuropilin-2 in axon guidance in the PNS and CNS.