Pulmonary diffusing capacity in healthy caucasian children
Pulmonary diffusing capacity in healthy caucasian children
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DOI：
10.1002/ppul.21564
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发表时间：
2012-05-01
影响因子：
3.1
通讯作者：
Eigen, Howard
中科院分区：
文献类型：
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作者：
Kim, Young-Jee;Hall, Graham L.;Eigen, Howard
以往对儿童肺弥散能力的研究在方法上存在很大差异；评估的受试者数量，并在最新的ATS/ERS指南之前进行。本研究的目的是利用现行国际指南和现代设备建立健康高加索儿童一氧化碳扩散能力（DLCO）和肺泡容积（VA）的参考范围。来自美国（N = 303）和澳大利亚（N = 176）的健康儿童根据现行ATS/ERS指南进行了可接受的单次呼吸肺弥散能力和肺泡容积测量。DLCO和V-A的自然对数与身高、年龄和年龄-性别交互项相关，而DLCO/V-A仅与身高和年龄-性别交互项相关。调整血红蛋白的DLCO （n = 303；仅限美国数据）导致DLCO减少了大约1%，但没有显著改变回归方程。在本数据集中，中心对DLCO或DLCO/VA没有影响，而澳大利亚儿童的V-A在统计学上较小（考虑身高、年龄和年龄-性别后的平均差异为0.14 L; P = 0.012）。我们报告说，扩散能力的结果可以从多个中心使用类似的设备和收集协议进行整理。利用整理的数据，我们推导了5-19岁健康高加索儿童肺弥散能力结局的回归方程。儿科肺科杂志2012；47: 469 - 475。(C) 2011 Wiley期刊公司
Previous studies of pulmonary diffusing capacity in children differed greatly in methodologies; numbers of subjects evaluated, and were performed prior to the latest ATS/ERS guidelines. The purpose of our study was to establish reference ranges for the diffusing capacity to carbon monoxide (DLCO) and alveolar volume (VA) in healthy Caucasian children using current international guidelines and contemporary equipment. Healthy children from the United States (N = 303) and from Australia (N = 176) performed acceptable measurements of single breath pulmonary diffusing capacity and alveolar volume according to current ATS/ERS guidelines. The natural log of DLCO and V-A were associated with height, age and an age-sex interaction term, while DLCO/V-A was related to height and the age-sex interaction term only. Adjustment of DLCO for hemoglobin (n = 303; USA data only) resulted is a small but significant decrease in DLCO of similar to 1% but did not significantly alter the regression equations. In this dataset there was no influence of center for DLCO or DLCO/VA, while Australian children had a statistically smaller V-A (mean difference 0.14 L after accounting for height, age and age-sex; P = 0.012). We report that diffusing capacity outcomes can be collated from multiple centers using similar equipment and collection protocols. Using collated data we have derived regression equations for pulmonary diffusing capacity outcomes in healthy Caucasian children aged 5-19 years. Pediatr Pulmonol. 2012; 47: 469-475. (C) 2011 Wiley Periodicals, Inc.