A Compact DNA Cube with Side Length 10 nm.
A Compact DNA Cube with Side Length 10 nm.
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DOI：
10.1002/smll.201501370
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发表时间：
2015-10-21
期刊：
影响因子：
--
通讯作者：
Simmel FC
中科院分区：
文献类型：
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作者：
Scheible MB;Ong LL;Woehrstein JB;Jungmann R;Yin P;Simmel FC
利用广义DNA砖的概念，利用不同长度的合成短寡核苷酸，构建了体积为Zeptoliter的小型紧凑DNA立方体。通过模仿DNA折纸技术的设计原理，与其他方法相比，DNA立方体提供了更高的稳定性和组装产量。超分辨成像显示了其作为纳米荧光探针的潜在应用。
A small and compact DNA cube with zeptoliter volume is constructed by means of a generalized DNA brick concept using short synthetic oligonucleotides with varying lengths. By mimicking design principles from the DNA origami technique, the DNA cube offers higher stability and assembly yields compared to other approaches. Its potential application as nanoscale fluorescent probe is demonstrated using super-resolution imaging.