Enhancement of experimental pancreatic cancer in Syrian golden hamsters by dietary fat.
Enhancement of experimental pancreatic cancer in Syrian golden hamsters by dietary fat.
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膳食脂肪增强叙利亚金仓鼠实验性胰腺癌的发生。
DOI：
10.1093/jnci/67.6.1327
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
P. Pour
中科院分区：
文献类型：
--
作者：
D. Birt;S. Salmasi;P. Pour
在随机饲养的叙利亚金仓鼠中研究了膳食脂肪对胰腺导管腺癌诱导和发展的影响。在单次注射 N-亚硝基双(2-氧代丙基)胺 (BOP)（10 毫克/公斤体重）之前或之后，喂食含有低脂肪 (LF) 或高脂肪 (HF) 水平玉米油 [4.5 或 18.0 g/385 千卡 (kcal)] 的饮食，分别贡献 10% 或 41% 的热量。对照仓鼠终生饲喂中等脂肪 (MD) 水平（9 克/385 kcal）的玉米油。当 BOP 治疗后饲喂 HF 饮食时，男性和女性的导管腺癌发病率均增加（LF 饮食为 16%；HF 饮食为 34%）。每只患癌动物的平均癌症数量也增加（LF 饮食，1.3；HF 饮食，3.0），但癌症发病率不受致癌物治疗前喂养的这些饮食的影响。所有治疗中导管腺瘤的发病率均较高，且不受饮食影响。然而，饲喂高频饮食的动物中腺瘤的数量有所增加。此外，在施用 BOP 后，饲喂 MF 和 HF 饮食的动物中腺泡细胞结节的发生率升高。这些结果表明，膳食脂肪改变了实验性胰腺导管腺癌的发展。
The effects of dietary fat on the induction and development of pancreatic ductular adenocarcinoma were studied in randombred Syrian golden hamsters. Diets containing low-fat (LF) or high-fat (HF) levels of corn oil [4.5 or 18.0 g/385 kilocalorie (kcal)], contributing 10 or 41% of the calories, respectively, were fed either before or after a single injection of N-nitrosobis(2-oxopropyl)amine (BOP) (10 mg/kg body wt). Control hamsters were fed corn oil at a medium-fat (MD) level (9 g/385 kcal) for life. The incidence of ductular adenocarcinomas increased in both males and females (LF diet, 16%; HF diet, 34%) when the HF diet was fed after BOP treatment. The average number of carcinomas per carcinoma-bearing animal also increased (LF diet, 1.3; HF diet, 3.0), but the carcinoma incidence was not influenced by these diets being fed before carcinogen treatment. The incidence of ductular adenomas was high with all treatments and was not influenced by diet. However, the number of adenomas was increased in animals fed HF diets. In addition, the incidence of acinar cell nodules was elevated in animals fed the MF and HF diets after BOP administration. These results showed that dietary fat modified the development of experimental ductular adenocarcinoma of the pancreas.