Role of the ubiquitin proteasome system in regulating skin pigmentation.
Role of the ubiquitin proteasome system in regulating skin pigmentation.
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DOI：
10.3390/ijms10104428
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发表时间：
2009-11-20
影响因子：
5.6
通讯作者：
Hearing VJ
中科院分区：
文献类型：
--
作者：
Ando H;Ichihashi M;Hearing VJ
皮肤、头发和眼睛的色素沉着由酪氨酸酶调节，酪氨酸酶是黑素细胞合成黑色素的关键限速酶。酪氨酸酶至少部分是由泛素蛋白酶体系统(UPS)内源性降解的。几种类型的遗传性色素缺乏疾病，如眼皮肤白化病和Hermansky-Pudlak综合征，涉及酪氨酸酶的异常加工和/或运输及其随后的降解，这可能是由于质量控制机制造成的。对碳水化合物修饰的研究表明，内质网(ER)中的酪氨酸酶是通过内质网相关蛋白的降解而被蛋白质降解的，而且酪氨酸酶在高尔基体中完全成熟后也可以发生降解。在调节UPS的内在因素中，脂肪酸被证明以相反的方式调节酪氨酸酶的降解，其方式是通过增加或减少泛素化的酪氨酸酶，从而导致蛋白酶体加速或减速其降解。
Pigmentation of the skin, hair and eyes is regulated by tyrosinase, the critical rate-limiting enzyme in melanin synthesis by melanocytes. Tyrosinase is degraded endogenously, at least in part, by the ubiquitin proteasome system (UPS). Several types of inherited hypopigmentary diseases, such as oculocutaneous albinism and Hermansky-Pudlak syndrome, involve the aberrant processing and/or trafficking of tyrosinase and its subsequent degradation which can occur due to the quality-control machinery. Studies on carbohydrate modifications have revealed that tyrosinase in the endoplasmic reticulum (ER) is proteolyzed via ER-associated protein degradation and that tyrosinase degradation can also occur following its complete maturation in the Golgi. Among intrinsic factors that regulate the UPS, fatty acids have been shown to modulate tyrosinase degradation in contrasting manners through increased or decreased amounts of ubiquitinated tyrosinase that leads to its accelerated or decelerated degradation by proteasomes.
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DOI：
10.1159/000468685
发表时间：
1993-01-01
期刊：
ENZYME & PROTEIN
影响因子：
--
作者：
DAHLMANN, B;BECHER, B;KUEHN, L
通讯作者：
KUEHN, L
影响因子：
4.4
作者：
Clarke, SD
通讯作者：
Clarke, SD
影响因子：
9.8
作者：
Hamel, FG;Upward, JL;Duckworth, WC
通讯作者：
Duckworth, WC
DOI：
10.1111/j.1600-0749.2004.00161.x
发表时间：
2004-08-01
期刊：
PIGMENT CELL RESEARCH
影响因子：
--
作者：
Hall, AM;Krishnamoorthy, L;Orlow, SJ
通讯作者：
Orlow, SJ
影响因子：
5.6
作者：
SAEKI, H;OIKAWA, A
通讯作者：
OIKAWA, A