Olfactory perceptual learning requires adult neurogenesis
Olfactory perceptual learning requires adult neurogenesis
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DOI：
10.1073/pnas.0907063106
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发表时间：
2009-10-20
影响因子：
11.1
通讯作者：
Mandairon, Nathalie
中科院分区：
文献类型：
--
作者：
Moreno, Melissa M.;Linster, Christiane;Mandairon, Nathalie
嗅觉功能需要感知学习才能适当地适应不断变化的气味环境。我们在这里表明，嗅球中的新生神经元不仅参与嗅觉知觉学习，而且是嗅觉知觉学习所必需的。首先，在反复接触气味剂后，小鼠对感知上相似的气味剂的辨别能力得到了改善。其次，这种辨别能力的提高伴随着嗅球内新生抑制性神经元存活率的提高，这些抑制性神经元优先参与处理习得的气味。最后，在气味暴露之前和期间阻断神经发生可以防止这种后天辨别能力的改善。因此，嗅觉感知学习是通过成人神经发生增强嗅球功能抑制来介导的。
Perceptual learning is required for olfactory function to adapt appropriately to changing odor environments. We here show that newborn neurons in the olfactory bulb are not only involved in, but necessary for, olfactory perceptual learning. First, the discrimination of perceptually similar odorants improves in mice after repeated exposure to the odorants. Second, this improved discrimination is accompanied by an elevated survival rate of newborn inhibitory neurons, preferentially involved in processing of the learned odor, within the olfactory bulb. Finally, blocking neurogenesis before and during the odorant exposure period prevents this learned improvement in discrimination. Olfactory perceptual learning is thus mediated by the reinforcement of functional inhibition in the olfactory bulb by adult neurogenesis.