NF-κB and Rheumatoid Arthritis: Will Understanding Genetic Risk Lead to a Therapeutic Reward?
NF-κB and Rheumatoid Arthritis: Will Understanding Genetic Risk Lead to a Therapeutic Reward?
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DOI：
10.1615/forumimmundisther.2013008408
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发表时间：
2013-04-01
期刊：
影响因子：
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通讯作者：
Scheinman R
中科院分区：
文献类型：
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作者：
Scheinman R
核因子-κB在类风湿性关节炎(RA)等自身免疫性疾病中发挥重要作用已为人所知。事实上，随着我们对核因子-κB是如何利用的了解的增加，我们很难找到一个在某种程度上与这个转录因子家族无关的过程。然而，部分源自全基因组关联研究的新数据表明，非常特殊的NF-κB途径成分的改变足以增加发生疾病的风险。在这里，我们回顾了已经确定了NF-κB途径的特定成分的数据，并考虑了已知的它们的作用机制以及这些机制如何在疾病过程中发挥作用。此外，还考虑了利用遗传信息预测类风湿关节炎。
NF-κB has long been known to play an important role in autoimmune diseases such as rheumatoid arthritis (RA). Indeed, as our understanding of how NF-κB is utilized has increased, we have been hard put to find a process not associated with this transcription factor family in some way. However, new data originating, in part, from genome-wide association studies have demonstrated that very specific alterations in components of the NF-κB pathway are sufficient to confer increased risk of developing disease. Here we review the data which have identified specific components of the NF-κB pathway, and consider what is known of their mechanisms of action and how these mechanisms might play into the disease process. In addition, the use of genetic information to predict RA is considered.